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| In chronic viral infections and cancer, T cells can be overstimulated by the amount of antigen present. Over time, they can lose their ability to function and clear the pathogen, which is known as a state of exhaustion. During this time, T cells increase expression of several inhibitory immune receptors like PD-1 and Tim-3. Blockade of these immunosuppressive markers could help reverse T cell exhaustion. Chew et al. specifically targeted TIGIT, a member of the CD28 family found on NK cells, CD8+ T cells, and CD4+ T cell subsets. BioLegend offers a new anti-TIGIT clone (A1513G), as well as antibodies for several other exhaustion markers. |
 Adapted from Chew, G.M. et al. 2016. PLoS Pathog. 12:E1005349. Pubmed |
| Chew et al. found that HIV patients had elevated expression of TIGIT and PD-1 on CD8+ T cells and correlated with disease progression. Ex vivo blockade of TIGIT or combinatorial blocking with PD-1 led to increased proliferation of CD8+ T cells as well as boosted production of IFN-γ and IL-2. This presents a novel suggestion that TIGIT can be targeted to reverse T cell exhaustion in the hopes that these revitalized cells can clear viral infections like HIV. |
Exhaustion Marker Reagents |
| Mouse Antibodies | Human Antibodies |
| Specificity | Clone | Specificity | Clone |
|---|---|---|---|
| CD152 (CTLA-4) | 9H10, UC10-4B9 | CD152 (CTLA-4) | A3.6B10.G1, BNI3, L3D10 |
| CD160 | 7H1 | CD160 | BY55 |
| CD223 (LAG-3) | C9B7W | CD223 (LAG-3) | 11C3C65, 7H2C65 |
| CD244.2 | m2B4 (B6)458.1 | CD244 | C1.7 |
| CD366 (Tim-3) | B8.2C12, RMT3-23 | CD366 (Tim-3) | F38-2E2 |
| TIGIT (Vstm3) | 1G9 | TIGIT (Vstm3) | A15153G |
| * The following formats for clone A15153G are coming soon: Brilliant Violet 421™, Brilliant Violet 605™, PE/Cy7, PE/Dazzle™ 594, and PerCP/Cy5.5. |
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Featured Products |
| Non-Antibody Chemical Probes | Western Blotting | |
| Helix NP™ Green | Purified anti-EGR2 Antibody | |
| Purified anti-ETS2 Antibody | ||
| Recombinant Proteins | Purified anti-GAB1 Antibody | |
| Recombinant Human Light (TNFSF14) (carrier-free) | Purified anti-HDAC5 Antibody | |
| Recombinant Human Persephin (carrier-free) | Purified anti-STAT2 Antibody | |
| Purified anti-ZAP70 Phospho (Tyr292) Antibody | ||
| Secondary Reagents | ||
| APC/Fire™ 750 Streptavidin |
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