Tau is a family of neuronal proteins that bind to microtubules (the neuron's transport system), and stabilize their formation and maintenance. In the human brain, Tau proteins constitute a family of 6 isoforms that is produced by alternative splicing of a single gene called MAPT (Microtubule-Associated Protein Tau). Research interest in tau proteins began to grow when tangled forms of these proteins were found to make up the paired helical filaments in brains of Alzheimer’s disease (AD) patients.
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