Blog Article

Naturally occurring soluble receptors are generated by several mechanisms including proteolytic cleavage of surface-bound ectodomains, alternative splicing, and extracellular release of membrane-bound receptors from exosomes.  Once generated, soluble receptors can act as either agonists or antagonists and dysregulation of these signaling pathways are often associated with immunopathologies, certain malignancies, and n eurodegenerative disorders.  We offer a wide-range of bioactive, recombinant soluble receptors that have been constructed to encode only the extracellular domain of the protein.

If you’re studying cell signaling pathways, try one of our phospho-specific antibodies for critical targets in pathways related to cell growth, proliferation, and health including: RPS6 Phospho (Ser235/Ser236), mTOR Phospho (Ser2448), ERK1/2 (Thr202/Tyr204), and p38 MAPK Phospho (Thr180/Tyr182).