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Synapses contain hundreds of proteins that impact higher level functions like movement, cognition, and memory. Proteins like Neuroligin-1, SALM, and SynCAM are involved with adhesion, helping to create synapses and improve communication between neurons. Ionotropic receptors form a single pore that spans the membrane. Activation of the receptor by neurotransmitters causes the pore to open and allows the direct passage of ions such as Ca2+ through the membrane. Ligands such as glutamate are excitatory, whereas other ligands like GABA are inhibitory. BioLegend provides cost-effective reagents to study these factors, which are of particular importance in neurodegenerative diseases that weaken synaptic connections.
Purified anti-SALM2 (LRFN1) Antibody Purified anti-VGlut2 Antibody
Staining of SALM2/LRFN1 on formalin-fixed paraffin-embedded rat brain tissue. Western Blot showing VGlut2 (N29/29) specificity. Lane 1: Molecular weight marker; Lane 2: Mouse brain membrane lysate; Lane 3: BSA negative control.
Presynaptic Proteins Postsynaptic Proteins Adhesion Molecules
CASK
Synaptotagmin-12
VGlut1
VGlut2		 PSD-93
PSD-95
SAPAP (pan reactive)
TARPγ2 		Neuroligin-1
Neuroligin-3
SALM2
SynCAM4
γ-protocadherin A
γ-protocadherin B2
GABAergic Receptors Glutaminergic Receptors
GABA(B)R2
GABBR1
GABRB3
GABRD		 GluR1
GluR2
NMDAR2B
BioLegend develops innovative reagents to support neuroscience research, with focus on the fields of neurodegeneration and neuroinflammation. We offer novel antibodies for detection of aggregate-specific species of α-Synuclein, a key protein involved in the pathogenesis of Parkinson’s disease.

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