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| Characterize the Ubiquitin-Proteasome Machinery |
| The ubiquitin-proteasome system is one of the major protein degradation pathways utilized by eukaryotic cells. Many tightly regulated processes, from ubiquitin conjugation to proteasomal assembly, must align for the system to function properly. Investigate each component of the ubiquitin-proteasome machinery with antibodies validated for multiple model organisms, including mouse, rat, and Drosophila. |
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| Featured Product |
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PSMD9, also known as p27, plays a role in modulating formation of the active 26S proteasome. Its function has been implicated in diseases like neurodegeneration, cancer, diabetes, and mental health disorders. Our purified anti-PSMD9 antibody is validated for western blotting and immunohistochemistry (IHC), and it is reactive against PSMD9 from humans, mice, and Drosophila.
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| Using Ubiquitin as an IHC Marker |
| Antibodies against ubiquitin can be used to visualize the presence of disease-related structures, such as cytoplasmic or extracellular inclusions. Gain a complete understanding of neurodegenerative disease by simultaneously staining for ubiquitin and protein aggregates like α-Synuclein, amyloid beta, and tau. |
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