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Purified anti-human Integrin αVβ6 Antibody

Pricing & Availability
Clone
53a.2 (See other available formats)
Regulatory Status
RUO
Other Names
Integrin alpha V beta 6
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
53a2_PURE_Integrin_Antibody_080822
Human colon carcinoma cell line (HT29) stained with purified anti-human Integrin αVβ6 (clone 53a.2) (filled histogram), or rat IgG2a, κ isotype control (open histogram) followed by PE goat anti-rat IgG.
  • 53a2_PURE_Integrin_Antibody_080822
    Human colon carcinoma cell line (HT29) stained with purified anti-human Integrin αVβ6 (clone 53a.2) (filled histogram), or rat IgG2a, κ isotype control (open histogram) followed by PE goat anti-rat IgG.
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384202 100 µg £264
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Description

Integrins are heterodimeric transmembrane receptors comprising alpha and beta subunits that function as cell anchoring and signaling molecules. The ITGAV gene encodes integrin alpha V, a type I integral membrane glycoprotein known as the vitronectin receptor α chain, or CD51. It forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. Integrin αV contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Integrin beta 6 is a protein that in humans is encoded by the ITGB6 gene. The β6 subunit only combines with αV to generate a single heterodimer. Integrin αVβ6 is a subtype of the integrin family expressed exclusively on epithelial cells. Integrin αVβ6 is usually expressed at low or undetectable levels in normal adult tissues but can be highly upregulated during pathological and physiological processes such as wound healing, fibrosis, inflammation, and cancer.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
ICC, IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Marsh D, el al. 2008. Cancer Res. 68:3295.
RRID
AB_2927857 (BioLegend Cat. No. 384202)

Antigen Details

Distribution

Epithelial cells

Function
Modulate innate immune surveillance, maintain epithelial stem cell quiescence
Ligand/Receptor
Serve as a fibronectin receptor
Cell Type
Epithelial cells
Biology Area
Angiogenesis, Cell Adhesion
Molecular Family
Adhesion Molecules
Gene ID
3685 View all products for this Gene ID 3694 View all products for this Gene ID
UniProt
View information about Integrin alphaVbeta6 on UniProt.org
Go To Top Version: 1    Revision Date: 08/08/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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