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| Synaptic function relies on the proper regulation of many processes, including vesicle transport, actin formation, and ion mobilization. Factors associated with neurodegenerative diseases, such as APP and α-synuclein, can disrupt synapse formation and neurotransmitter release. Diversify your toolset with our versatile reagents to uncover the complexities of synapse biology, and how it relates to neurodegeneration. |
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| Actin is a critical component of the cytoskeleton in neurons, and must be regulated properly for optimal synaptic function. Actin is particularly important for forming post-synaptic dendritic spines, which can dictate synapse strength. Visualize and characterize actin formation in neurons with Flash Phalloidin™ probes: fluorescently conjugated peptides that label and stabilize F-actin proteins.
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 Primary mouse astrocytes stained with anti-GFAP Alexa Fluor® 594 (red), Flash Phalloidin™ Green 488 (green), and DAPI (blue). |
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| Find the freedom to pursue multiple questions and explore different aspects of synapse biology with sampler kits: economical sets of antibodies validated for IHC and western blot that target various proteins or protein modifications. |
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 FFPE AD brain tissue stained with anti-Ubiquitin antibody (P4G7). Arrows point to neuritic plaques and arrowhead points to neuropil threads. |
The ubiquitin pathway can regulate axon growth, signal endocytosis, and contribute to synaptic plasticity. Ubiquitin is also a common marker for neurodegenerative pathologies. For example, ubiquitin staining can detect amyloid plaques, which cause synaptic dysfunction in Alzheimer’s disease. Learn more about how ubiquitin can be used as an IHC marker for neurodegeneration.
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