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Purified anti-HSPA1L Antibody

Pricing & Availability
Clone
BL28548 (See other available formats)
Regulatory Status
RUO
Other Names
HSPA1L, Heat shotck 70 kDa protein 1-like
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
BL28548_Purified_HSPA1L_Antibody_1_111918.png
Western blot of purified anti-HSPA1L antibody (clone BL28548). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • BL28548_Purified_HSPA1L_Antibody_1_111918.png
    Western blot of purified anti-HSPA1L antibody (clone BL28548). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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854801 25 µg 106 CHF
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Description

HSPA1L is a chaperone protein belonging to the heat shock protein 70 (HSP70) family. HSPA1L participates in multiple biological processes, such as apoptosis, cell growth and differentiation, by facilitating the folding of newly-translated proteins and the degradation of misfolded proteins. Overexpression of HSPA1L mitigates symptoms of neurodegenerative diseases including Alzheimer’s Diseases, and Parkinson’s diseases, suggesting that HSPA1L has the potential to serve as a diagnostic/prognostic biomarker for these disorders.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2783439 (BioLegend Cat. No. 854801)

Antigen Details

Structure
HSPA1L is a 641 amino acid protein with an apparent molecular mass of ~ 70 kD.
Distribution

Tissue Distribution: Highly expressed in testis. Ubiquitously expressed in low level in all tissues.
Cellular Distribution: Cytosol, extracellular, and nucleus

Function
HSPA1L is a chaperone protein that facilitates folding of newly synthesized proteins as well as degradation of misfolded proteins.
Interaction
Known to interact with PRKN and HIF-1alpha
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Antigen References
  1. Huusko JM, et al. 2018. PLoS Genet. 14(7):e1007394
  2. Lee JH, et al. 2017. Oncogene. 36(47):6555
  3. Takahashi S, et al. 2017, Genome Med. 9(1):8
Gene ID
3305 View all products for this Gene ID 15482 View all products for this Gene ID 24963 View all products for this Gene ID
UniProt
View information about HSPA1L on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.20.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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