Interested in schizophrenia (SZ) research? SZ, a disease affecting individual’s perception of reality and social behavior, has been associated with altered dopamine (DA) neurotransmitter activity and aberrant synaptic pruning. Oversensitivity of certain DA receptors or excess availability of the neurotransmitter itself is believed to be one of the causal factors in schizophrenia. The most common anti-psychotic medication used to treat SZ are dopamine antagonists which help reduce DA activity. Excessive synaptic elimination is due to a defect in the pruning program which leads to fewer synaptic connections in multiple regions of the brain and loss of the grey matter. Studies suggest that excessive complement activity plays an important role in reducing the number of synapses in the brain of SZ patients. BioLegend is proud to offer antibodies for detection of components of the complement system, dopaminergic neuron markers, dopamine receptors and proteins involved in dopamine trafficking.
Description Clone Reactivity Applications Cat.No.
Purified anti-complement C3b/iC3b Antibody 3E7/C3b Human, Non-Human Primate ELISA, FC 846102
Biotin anti-human C5a/C5a(desArg)/C5 Antibody G25/2 Human WB, ELISA, IP 518305, 518306
Purified anti-CD93 (Cq1 receptor) Antibody 74.5.2 Human, Mouse, Rat WB, ELISA, FC, IP 920601
Purified anti-Dopamine Transporter, EL2 Antibody Poly28163 Human, Monkey WB, IHC 816301
PE anti-human Dopamine Receptor D1 L205G1 Human FC 366403, 366404
Purified anti-Dopamine D3 receptor Antibody N331/19 Human WB, IHC, ICC 827501
Purified anti-Tyrosine Hydroxylase Antibody 2/40/2015 Human, Mouse, Rat WB, IHC 818001
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