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- Clone
- TX70 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD300LF, CD300f, CMRF35-like molecule 1, Myeloid-associated immunoglobulin-like receptor 5
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
The myeloid-associated immunoglobulin-like receptor family (CD300) consists of nine activating or inhibitory cell surface receptors preferentially expressed on myloid cells and are encoded by the genes in a small cluster on mouse chromosome 11. MAIR-V is one of the family members. MAIR-V regulates the activation of myeloid cells. It has been reported that cross-linking MAIR-V with anti-MAIR-V monoclonal antibody induced cell death in peritoneal macrophages as well as transfectants. Data suggested that MAIR-V is one of the inhibitory receptors in the family. The functional of characteristics of this receptor are still not clear. Monoclonal antibody TX70 recognized both MAIR-Va and MAIR-Vb.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- MAIR-V transfectant (BW5147)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
- Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2074118 (BioLegend Cat. No. 132702)
Antigen Details
- Structure
- MAIR-V belongs to the myeloid-associated immunoglobulin-like receptor family. It has two isoforms, MAIR-Va and MAIR-Vb. MAIR-V contains a consensus immunoreceptor tyrosine-based switching motif (ITSM) as well as two ITIMs in the cytoplasmic tail.
- Distribution
- It was reported that CD300LF is expressed on myeloid cells, including macrophages, neutrohils, DCs, and bone marrow derived mast cells. The expression profile of MAIR-V is still incompletely understood.
- Cell Type
- Macrophages, Neutrophils, Dendritic cells, Mast cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Can Ismail, et al. 2008. Hybridoma. 27 (1):59-61
2. Can Ismail, et al. 2008. J. Immunol. Sep; 180:207-213
3. Totsumoto K, et al. 2003. J. Exp. Med. 198:223-233 - Gene ID
- 246746 View all products for this Gene ID
- UniProt
- View information about MAIR-V on UniProt.org
Related FAQs
Other Formats
View All MAIR-V Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse MAIR-V | TX70 | FC |
| PE anti-mouse MAIR-V | TX70 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse MAIR-V
-
PE anti-mouse MAIR-V
MAIR-V transfected cells stained with TX70-PE
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