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Cleavage of amyloid precursor protein by secretases generates functional protein fragments, including Aβ which has been characterized for its role in Alzheimer's disease. As each of these fragments function differently in neurodegeneration, it is important to have antibodies against each cleavage product. Learn more about our anti‐amyloid antibodies that can specifically detect APP cleavage products.
APP Cleavage Products and their Functions
  • Aβ‐ Deposition of Aβ plaques is a hallmark of Alzheimer's disease. Though they only differ by 2 amino acids, Aβ42 is more likely to form oligomers than Aβ40.
  • sAPPα‐ Modulates synaptic transmission and plasticity through GABA receptors.
  • sAPPβ‐ Involved in pruning synapses during development and influences stem cell differentiation.
  • C‐Terminal Fragments (C83 and C99)‐ Interact with adaptor and signaling proteins and play a role in protein trafficking.
  • AICD‐ Negative regulator of proliferation in progenitor cells and forms a complex with transcriptional regulators to alter gene expression.
Interested in trying our anti‐amyloid antibodies? Take advantage of our Neuroscience Sample Size antibody promotion and receive a 50% discount on select sample size antibodies.
Clone Specificity
  Aβ 1‐40 Aβ 1‐42 APP AICD sAPPα sAPPβ C‐terminal
Fragment
6E10 • • •    •    
12F4   •           
11A50‐B10 •             
3A1 • •           
Poly8119       •       
C1⁄6.1             •
Poly8134            •  
 Buffers
 Blocking Reagents
 Detection Kits
 Retrieve-All Antigen Unmasking Systems
IHC staining using Alexa Fluor® 647 anti‑β‑amyloid, 1‑16 antibody (clone 6E10) on FFPE Alzheimer's disease brain tissue. IHC staining using Purified anti‑β‑amyloid, 1‑40 antibody (clone 11A50‑B10) on FFPE Alzheimer's disease brain tissue.
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