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The neural synapse most often occurs between axon of one neuron and the dendrites of another and is composed of hundreds of proteins that function together to coordinate the exquisitely tuned signals that form the physical basis for higher nervous system functions, such as cognition, memory, or movement. Synapses adapt over time and can weaken or strengthen in response to a number of factors, a phenomenon which is termed neural plasticity. Neurodegenerative diseases, such as Alzheimer’s or Parkinson’s, display a loss of synaptic function and a subsequent degradation of these structures. This degeneration occurs more prominently at particular locations in the central nervous system for certain neurodegenerative diseases, such as the substania nigra for Parkinson’s disease, which is highly enriched in synapses that transmit the neurotransmitter dopamine. Investigation into the mechanisms that lead to dysfunction and synaptic loss may provide new avenues for preventative or therapeutic intervention.
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