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Microglia
Microglia are the resident macrophages in the brain and spinal cord. They act as the first line of active immune defense and are responsible for protecting the central nervous system (CNS) from pathogenic insults. Microglia constantly survey and scan the CNS, and are very sensitive to changes in their environment. Under normal physiological conditions, microglia reside in a resting state (ramified), where they function as housekeepers to clean up cellular debris and apoptotic cells by phagocytosis. Microglia transition to an activated state under acute inflammatory conditions such as invading infectious agents, neuronal damage, and the presence of pathogenic protein aggregates produced in neurodegenerative disorders.
Activated microglia can polarize into M1 (pro-inflammatory) or M2 (anti-inflammatory) state depending on the nature of the inflammatory stimulus. In the M1 state, microglia respond to injury or infection by producing oxidative metabolites and pro-inflammatory cytokines and chemokines to induce infiltration of peripheral leukocytes to combat and clear the insult or injury. In the M2 state, microglia antagonize the M1 pro-inflammatory responses by secreting anti-inflammatory cytokines to facilitate phagocytosis of cell debris, and promote the reconstruction of the extracellular matrix (ECM) and tissue repair. The M2 microglia also produce neurotrophic factors to support neuronal cell health and survival.
BioLegend is proud to offer a variety of cell type-specific antibodies including those for microglia detection for your research needs. BioLegend cell marker antibodies are provided in various formats for use in multiple applications.

Microglia Markers
Human
Description Clone Reactivity Cat. No.
Alexa Fluor® 594 anti-human CD11b Antibody ICRF44 Human, Non-Human Primates, Swine 301340
Brilliant Violet 421™ anti-human CD11b Antibody ICRF44 Human, Non-Human Primates, Swine 301324
Purified anti-human CD11b Antibody ICRF44 Human, Non-Human Primates, Swine 301302
Alexa Fluor® 647 anti-human CD45 Antibody HI30 Human, Non-Human Primates 304056
Purified anti-human CD45 Antibody HI30 Human, Non-Human Primates 304001
Alexa Fluor® 488 anti-human CD68 Antibody Y1/82A Human 333812
Purified anti-human CD68 Antibody Y1/82A Human 333802
Purified anti-CX3CR1 Antibody 8E10.D9 Human, Mouse 824001
Mouse
Description Clone Reactivity Cat. No.
Alexa Fluor® 594 anti-mouse CD45 Antibody 30-F11 Mouse 103144
Purified anti-mouse CD45 Antibody 30-F11 Mouse 103102
Alexa Fluor® 594 anti-mouse CD68 Antibody FA-11 Mouse 137020
APC anti-mouse CD68 Antibody FA-11 Mouse 137008
Purified anti-CX3CR1 Antibody 8E10.D9 Mouse, Human 824001

Learn more about Neuroinflammation

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