Synapses contain hundreds of proteins that impact higher level functions like movement, cognition, and memory. Proteins like Neuroligin-1, SALM, and SynCAM are involved with adhesion, helping to create synapses and improve communication between neurons. Ionotropic receptors form a single pore that spans the membrane. Activation of the receptor by neurotransmitters causes the pore to open and allows the direct passage of ions such as Ca2+ through the membrane. Ligands such as glutamate are excitatory, whereas other ligands like GABA are inhibitory. BioLegend provides cost-effective reagents to study these factors, which are of particular importance in neurodegenerative diseases that weaken synaptic connections. |
Purified anti-SALM2 (LRFN1) Antibody | Purified anti-VGlut2 Antibody |
Staining of SALM2/LRFN1 on formalin-fixed paraffin-embedded rat brain tissue. | Western Blot showing VGlut2 (N29/29) specificity. Lane 1: Molecular weight marker; Lane 2: Mouse brain membrane lysate; Lane 3: BSA negative control. |
Presynaptic Proteins | Postsynaptic Proteins | Adhesion Molecules |
---|---|---|
CASK Synaptotagmin-12 VGlut1 VGlut2 |
PSD-93 PSD-95 SAPAP (pan reactive) TARPγ2 |
Neuroligin-1 Neuroligin-3 SALM2 SynCAM4 γ-protocadherin A γ-protocadherin B2 |
GABAergic Receptors | Glutaminergic Receptors | |
---|---|---|
GABA(B)R2 GABBR1 GABRB3 GABRD |
GluR1 GluR2 NMDAR2B |
BioLegend develops innovative reagents to support neuroscience research, with focus on the fields of neurodegeneration and neuroinflammation. We offer novel antibodies for detection of aggregate-specific species of α-Synuclein, a key protein involved in the pathogenesis of Parkinson’s disease. Visit the webpage… |
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