Loading...

PE anti-mouse IFN-γ Antibody

Pricing & Availability
Clone
XMG1.2 (See other available formats)
Regulatory Status
RUO
Other Names
Interferon-γ, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF)
Isotype
Rat IgG1, κ
Ave. Rating
Submit a Review
Product Citations
publications
XMG1.2
PMA/Ionomycin-stimulated BALB/c T-cells were stained with CD3 FITC and XMG1.2 PE
  • XMG1.2
    PMA/Ionomycin-stimulated BALB/c T-cells were stained with CD3 FITC and XMG1.2 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
505807 25 µg 32€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
505808 100 µg 88€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

IFN-γ is a potent multifunctional cytokine which is secreted primarily by activated NK cells and T cells. Originally characterized based on anti-viral activities, IFN-γ also exerts anti-proliferative, immunoregulatory, and proinflammatory activities. IFN-γ can upregulate MHC class I and II antigen expression by antigen-presenting cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
E. coli-expressed, recombinant mouse IFN-γ
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The IFN-γ antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

ELISA1-4,11,14 or ELISPOT5 Detection: The biotinylated XMG1.2 antibody is useful as a detection antibody for a sandwich ELISA or ELISPOT assay, when used in conjunction with purified R4-6A2 antibody (Cat. No. 505702/505706) as the capture antibody and recombinant mouse IFN-γ (Cat. No. 575309) as the standard.
ELISA or ELISPOT Capture: The purified XMG1.2 antibody is useful as a capture antibody for a sandwich ELISA or ELISPOT assay, when used in conjunction with biotinylated R4-6A2 antibody (Cat. No. 505704) as the detection antibody and recombinant mouse IFN-γ (Cat. No. 575309) as the standard. The LEAF™ purified antibody is suggested for ELISPOT capture (Cat. No. 505812).
Flow Cytometry7,8,12,13,16: The fluorochrome-labeled XMG1.2 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IFN-γ-producing cells within mixed cell populations.
Neutralization1-3,9,10: The XMG1.2 antibody can neutralize the bioactivity of natural or recombinant IFN-γ. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IFN-γ bioactivity in vivo and in vitro (Cat. No. 505812). For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 505834) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).
Additional reported applications (for the relevant formats) include: Western blotting, immunohistochemical staining of frozen tissue sections6,22,23, and immunocytochemistry.
Note: For testing mouse IFN-γ in serum, plasma or supernatant, BioLegend's ELISA Max™ Sets (Cat. No. 430801 to 430806) are specially developed and recommended.

Application References

(PubMed link indicates BioLegend citation)
  1. Abrams J, et al. 1992. Immunol. Rev. 127:5. (ELISA, Neut)
  2. Sander B, et al. 1993. J. Immunol. Meth. 166:201. (ELISA, Neut)
  3. Abrams J, et al. 1995. Curr. Prot. Immunol. John Wiley and Sons, New York. Unit 6.20. (ELISA, Neut)
  4. Yang X, et al. 1993. J. Immunoassay 14:129. (ELISA)
  5. Klinman D, et al. 1994. Curr. Prot. Immunol. John Wiley and Sons, New York. Unit 6.19. (ELISPOT)
  6. Sander B, et al. 1991. Immunol. Rev. 119:65. (IHC)
  7. Ferrick D, et al. 1995. Nature 373:255. (FC)
  8. Ko SY, et al. 2005. J. Immunol. 175:3309. (FC) PubMed
  9. Peterson KE, et al. 2000. J. Virol. 74:5363. (Neut)
  10. DeKrey GK, et al. 1998. Infect. Immun. 66:827. (Neut)
  11. Dzhagalov I, et al. 2007. J. Immunol. 178:2113. (ELISA)
  12. Lawson BR, et al. 2007. J. Immunol. 178:5366. (FC)
  13. Lee JW, et al. 2006. Nature Immunol. 8:181. (FC) PubMed
  14. Xu G, et al. 2007. J. Immunol. 179:5358. (ELISA) PubMed
  15. Montfort M, et al.2004. J. Immunol. 173:4084. PubMed
  16. Haring JS, et al. 2008. J. Immunol. 180:2855. (FC) PubMed
  17. Jordan JM, et al. 2008. Infect Immun. 76:3717. PubMed
  18. Tonkin DR, et al. 2008. J. Immunol. 181:4516. PubMed
  19. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  20. Cui Y, et al. 2009. Invest. Ophth. Vis. Sci. 50:5811. (FC) PubMed
  21. Mykkanen OT, et al. 2014. PLoS One. 9:114790. PubMed
  22. Yokogawa M, et al. 2013. Mol. Carcinog. 52:760. (IHC)
  23. Mottram PL, et al. 1998. J Immunol. 161:602. (IHC)
Product Citations
  1. Wang H, et al. 2013. J Immunol. 191:6010. PubMed
  2. Kim K, et al. 2016. PLoS One. 11: 0148576. PubMed
  3. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  4. Chen Y, et al. 2020. Virol Sin. . PubMed
  5. Bradley CP et al. 2017. Cell host & microbe. 22(5):697-704 . PubMed
  6. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  7. Toubai T, et al. 2017. Blood Adv. 1.095138889. PubMed
  8. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  9. Sandu I, et al. 2020. Nat Commun. 11:4454. PubMed
  10. Wang HH, et al. 2022. J Biomed Sci. 29:36. PubMed
  11. Miki H, et al. 2020. J Immunol. 204:1892. PubMed
  12. Zhang H, et al. 2022. Eur J Immunol. 52:978. PubMed
  13. Jia JJ, et al. 2022. J Leukoc Biol. 112:157. PubMed
  14. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  15. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  16. Tu J, et al. 2022. Cancer Sci. 113:2496. PubMed
  17. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  18. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  19. Kang IH, et al. 2022. iScience. 25:104818. PubMed
  20. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  21. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  22. Tan TCJ, et al. 2022. Nat Commun. 13:7796. PubMed
  23. Wang Z, et al. 2022. Cell Rep. 41:111890. PubMed
  24. Chan L, et al. 2022. Cells. 12: . PubMed
  25. Liu H, et al. 2023. Cell Death Differ. :. PubMed
  26. Mandour MF, et al. 2023. Front Med (Lausanne). 9:1057252. PubMed
  27. Kuehm LM, et al. 2021. Cancer Immunol Res. 9:227. PubMed
  28. Khojandi N, et al. 2021. Cancer Immunol Res. 9:214. PubMed
  29. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  30. Wu MJ, et al. 2022. Cancer Discov. 12:812. PubMed
  31. Tan L, et al. 2022. Aging Dis. 13:1562. PubMed
  32. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  33. Cheng C, et al. 2022. Cell Mol Gastroenterol Hepatol. 15:261. PubMed
  34. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  35. Wang X, et al. 2023. J Immunother Cancer. 11:. PubMed
  36. Lu C, et al. 2023. Antiviral Res. 212:105556. PubMed
  37. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  38. Tan X, et al. 2023. Adv Sci (Weinh). 10:e2206768. PubMed
  39. Martins Nascentes Melo L, et al. 2023. J Immunother Cancer. 11:. PubMed
  40. Li D, et al. 2023. Ann Med. 55:2189295. PubMed
  41. Zuo B, et al. 2023. Clin Transl Oncol. . PubMed
  42. Pandit M, et al. 2023. Nat Commun. 14:2593. PubMed
  43. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  44. Deng G, et al. 2023. Cancers (Basel). 15:. PubMed
  45. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  46. Gao Y, et al. 2023. iScience. 26:106729. PubMed
  47. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  48. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  49. Yang QC, et al. 2023. iScience. 26:106916. PubMed
  50. Gern BH, et al. 2021. Cell Host Microbe. 29(4):594-606.e6. PubMed
  51. Lin W, et al. 2020. Theranostics. 10:4871. PubMed
  52. Zhou J, et al. 2019. Immunity. 50:403. PubMed
  53. Shi L, et al. 2019. Theranostics. 9:4115. PubMed
  54. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  55. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  56. Zhou J, et al. 2021. Int J Med Sci. 18:3516. PubMed
  57. Kim D, et al. 2021. Nanomicro Lett. 13:31. PubMed
  58. Xia S, et al. 2014. J Leukoc Biol. 95:733. PubMed
  59. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  60. Dong L, et al. 2021. Cancer Cell. . PubMed
  61. Gálvez-Cancino F, et al. 2017. Vaccine. 10.1016/j.vaccine.2017.06.041. PubMed
  62. Wang X, et al. 2018. Int Immunopharmacol. 56:249. PubMed
  63. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  64. Yang F, et al. 2021. Front Microbiol. 11:512581. PubMed
  65. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  66. Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
  67. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  68. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  69. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  70. Zhang S, et al. 2022. Cell Death Dis. 13:844. PubMed
  71. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  72. Chakrabarti J, et al. 2018. Oncotarget. 9:37439. PubMed
  73. Oyarce C, et al. 2018. Front Immunol. 8:1794. PubMed
  74. Mayer RL, et al. 2022. Nat Commun. 13:6075. PubMed
  75. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  76. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  77. Herman JD, et al. 2021. Nat Commun. 12:6853. PubMed
  78. Galeano Niño JL, et al. 2020. J Cell Sci. . PubMed
  79. Saito S, et al. 2020. Nutrients. 12:. PubMed
  80. Koenecke C, et al. 2012. J Immunol. 189:2890. PubMed
  81. Michel M, et al. 2012. Proc Natl Acad Sci U S A. 109:17459. PubMed
  82. Wang Y, et al. 2016. Sci Rep. 6:31881. PubMed
  83. Chen D, et al. 2018. Nat Commun. 9:873. PubMed
  84. Papafragkos I, et al. 2022. Front Immunol. 13:889075. PubMed
  85. Xiong A, et al. 2022. EBioMedicine. 83:104239. PubMed
  86. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  87. Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
  88. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  89. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  90. Ning X, et al. 2019. Mol Cell. 74:19. PubMed
  91. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  92. Dai B, et al. 2022. Theranostics. 12:7603. PubMed
  93. Kuttke M, et al. 2022. Front Immunol. 13:695576. PubMed
  94. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  95. Subbiah J, et al. 2022. NPJ Vaccines. 7:68. PubMed
  96. Wang C, et al. 2021. Cell Rep. 37:110021. PubMed
  97. Wan Y, et al. 2014. Vaccine. 41:241. PubMed
  98. Sandrock I, et al. 2015. PLoS One. 10: 0145010. PubMed
  99. Koren N, et al. 2021. Cell Host Microbe. 29(2):197-209.e5. PubMed
  100. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  101. Probst P, et al. 2017. Cancer Res. 77:3644. PubMed
  102. Caronni N, et al. 2018. Cancer Res. 78:1685. PubMed
  103. An J, et al. 2022. iScience. 25:103570. PubMed
  104. Han JP, et al. 2022. Sci Adv. 8:eabj6901. PubMed
  105. Yu Y, et al. 2022. Nat Commun. 13:6357. PubMed
  106. Shami A, et al. 2015. Sci Rep. 5: 13904. PubMed
  107. Gungor B, et al. 2014. Sci Transl Med. 6:235. PubMed
  108. Hegde S, et al. 2020. Cancer Cell. 37(3):289-307. PubMed
  109. Srey MT, et al. 2020. PLoS Negl Trop Dis. 14:e0008842. PubMed
  110. Chen D, et al. 2022. J Neuroinflammation. 19:112. PubMed
  111. Cha SE, et al. 2021. Oncoimmunology. 10:1899469. PubMed
  112. Canton J, et al. 2021. Nat Immunol. 22:140. PubMed
  113. Cho K, Hill A 2008. J Immunol Methods. 330:137. PubMed
  114. Condotta S, et al. 2015. J Immunol. 195: 116 - 125. PubMed
  115. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  116. Gong Y, et al. 2020. Cell Metabolism. 33(1):51-64.e9. PubMed
  117. Espinosa JR, et al. 2018. Front Immunol. 9:1371. PubMed
  118. Hundt M, et al. 2009. J Immunol. 183:1685. PubMed
  119. Duan RN, et al. 2021. J Neuroinflammation. 18:145. PubMed
  120. Hanasoge Somasundara AV, et al. 2021. Cell Rep. 37:110099. PubMed
  121. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  122. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  123. Sartorius R, et al. 2015. EMBO Mol Med. 7: 973 - 988. PubMed
  124. Mirando AC, et al. 2020. Oncoimmunology. 9:1760685. PubMed
  125. Garo LP, et al. 2019. Cell Rep. 28:3353. PubMed
  126. Li W, et al. 2019. Nat Commun. 10:3349. PubMed
  127. Yan Y, et al. 2018. JCI Insight. 3. PubMed
  128. Place D, et al. 2017. PLoS One. 10.1371/journal.pone.0190384. PubMed
  129. Palazon A, et al. 2017. Cancer Cell. . 10.1016/j.ccell.2017.10.003. PubMed
  130. Reese B, et al. 2020. J Immunol. 205:3218. PubMed
  131. Ma Y, et al. 2013. J Immunol. 190:5588. PubMed
  132. Dutow P, et al. 2014. J Infect Dis. 209:1269. PubMed
  133. QT N, et al. 2015. Antimicrob Agents Chemother. 59: 6308-6316. PubMed
  134. Latasa C, et al. 2016. PLoS One. 11: 0161216. PubMed
  135. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  136. Galeano Niño JL, et al. 2020. J Cell Sci. 133:00:00. PubMed
  137. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  138. Marcus A et al. 2018. Immunity. 49(4):754-763 . PubMed
  139. Bosnjak B, et al. 2021. Front Immunol. 12:772240. PubMed
  140. Tian X, et al. 2022. J Cell Mol Med. 26:693. PubMed
  141. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  142. Shen JZ, et al. 2020. Cell. 184(2):352-369.e23. PubMed
  143. Ren Y, et al. 2015. Sci Rep. 5: 18099. PubMed
  144. Kraus Z, et al. 2008. J Immunol. 181:7800. PubMed
  145. Lin W, et al. 2019. EBioMedicine. 49:133. PubMed
  146. Leclerc M, et al. 2019. Nat Commun. 10:3345. PubMed
  147. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  148. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  149. Yang Z, et al. 2021. Onco Targets Ther. 14:4239. PubMed
  150. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  151. Tanaka Y, et al. 2020. Sci Rep. 10:17284. PubMed
  152. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  153. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  154. Koelwyn GJ, et al. 2020. Nat Med. 1452:26. PubMed
  155. Xu P, et al. 2020. Cancer Immunol Res. 8:1193. PubMed
  156. Karandikar SH, et al. 2019. JCI Insight. 5. PubMed
  157. Bartolacci C, et al. 2018. Cancer Immunol Res. 1.281944444. PubMed
  158. Montfort M, et al. 2004. J Immunol. 173:4084. PubMed
  159. Xu Q, et al. 2021. Theranostics. 11:1937. PubMed
  160. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  161. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  162. Hirata SI, et al. 2020. Allergy. 75:1939. PubMed
  163. Castiglioni P, et al. 2017. PLoS Negl Trop Dis. 10.1371/journal.pntd.0005240. PubMed
  164. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  165. Roy S, et al. 2019. Front Immunol. 2.404166667. PubMed
  166. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  167. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  168. Zhang J, et al. 2018. Nature. 553:91. PubMed
  169. Dong M, et al. 2022. J Immunother Cancer. 10:. PubMed
  170. Ye Q, et al. 2022. NPJ Vaccines. 7:84. PubMed
  171. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  172. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  173. Miao W, et al. 2020. J Immunol. 1486:204. PubMed
  174. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  175. Mandour MF, et al. 2020. Infect Agent Cancer. 15:30. PubMed
  176. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  177. Li H, et al. 2021. Front Immunol. 12:739605. PubMed
  178. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  179. Mah-Som AY, et al. 2021. Cell Reports. 35(9):109209. PubMed
  180. Lee J, et al. 2007. Nat Immunol. 8:181. PubMed
  181. Tian D, et al. 2019. Nat Commun. 10:4246. PubMed
  182. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  183. Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
  184. Johnson RM, et al. 2021. Front Immunol. 11:614697. PubMed
  185. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  186. Molgora M, et al. 2020. Cell. 182:886. PubMed
  187. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  188. Tomaru U et al. 2019. Cell reports. 26(3):639-651 . PubMed
  189. Fang W, et al. 2021. J Exp Clin Cancer Res. 40:4. PubMed
  190. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  191. Rousso-Noori L, et al. 2021. Nat Commun. 12:3615. PubMed
  192. Wang Y, et al. 2021. Front Immunol. 11:601601. PubMed
  193. Prakash MD, et al. 2021. PLoS One. 16:e0247492. PubMed
  194. Zhang X, et al. 2020. J Cancer. 11:648. PubMed
  195. Zhao K, et al. 2021. Biomed Res Int. 7619849:2020. PubMed
  196. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  197. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  198. Nakao R, et al. 2022. NPJ Vaccines. 7:153. PubMed
  199. McAusland TM, et al. 2021. Mol Ther Oncolytics. 20:306. PubMed
  200. Li H, et al. 2022. iScience. 25:104481. PubMed
  201. Schmit T, et al. 2022. Cell Rep. 38:110456. PubMed
  202. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  203. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  204. Gaylo A, et al. 2013. Transpl Immunol. 20:163. PubMed
  205. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  206. Kim YS, et al. 2018. Front Immunol. 9:1093. PubMed
  207. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  208. Dourcy M, et al. 2020. Mucosal Immunol. 13:799. PubMed
  209. Kerdidani D, et al. 2022. J Exp Med. 219:. PubMed
  210. Zheng Y, et al. 2022. Transl Res. :. PubMed
  211. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  212. Chow AK, et al. 2021. Cellular and Molecular Gastroenterology and Hepatology. :. PubMed
  213. Tripathi D, et al. 2016. Nat Commun. 7:13896. PubMed
  214. Brenner E, et al. 2020. Nat Commun. 11:1335. PubMed
  215. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  216. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  217. Bing Wu et al. 2018. Immunity. 49(5):886-898 . PubMed
  218. Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed
  219. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  220. Yang F, et al. 2021. Nat Commun. 12:3424. PubMed
  221. Li X, et al. 2021. Front Cell Dev Biol. 9:647713. PubMed
RRID
AB_315401 (BioLegend Cat. No. 505807)
AB_315401 (BioLegend Cat. No. 505808)

Antigen Details

Structure
Cytokine; dimer; 40-80 kD (Mammalian)
Bioactivity
Antiviral/antiparasitic activities; inhibits proliferation; enhances MHC class I and II expression on APCs
Cell Sources
CD8+ and CD4+ T cells, NK cells
Cell Targets
T cells, B cells, macrophages, NK cells, endothelial cells, fibroblasts
Receptors
IFN-γRα (CDw119) dimerized with IFN-γRβ (AF-1)
Cell Type
Tregs
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego.
2. De Maeyer E, et al. 1992. Curr. Opin. Immunol. 4:321.
3. Farrar M, et al. 1993. Annu. Rev. Immunol. 11:571.
4. Gray P, et al. 1987. Lymphokines 13:151.

Regulation
Upregulated by IL-2, FGF-basic, EGF; downregulated by 1-α-25-Dihydroxy vitamin D3, dexamethasone
Gene ID
15978 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
IFN-gamma
Specificity Alt (DOES NOT SHOW ON TDS):
IFN-γ
App Abbreviation (DOES NOT SHOW ON TDS):
ICFC
UniProt
View information about IFN-gamma on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 12.11.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account