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- Clone
- N327/95 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GluN2A/NR2A glutamate receptor, Glutamate receptor ionotropic, NMDA 2A, N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor subunit 2A, glutamate [NMDA] receptor subunit epsilon-1, Grin2a
- Previously
-
Covance Catalog# MMS-5146
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Western blot of purified anti-NMDAR2A antibody (clone N327/95). Lane 1: Molecular weight marker; Lane 2: 20 µg of mouse brain membrane lysate; Lane 3: 20 µg of rat brain membrane lysate. The blot was incubated with 10 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 832102 | 25 µL | 67€ | ||||
| 832101 | 100 µL | 132€ | ||||
Glutamate activated Ion channels that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDA receptor plays an essential role in the induction of LTP in the CA1 and dentate areas of the hippocampus as the specific NMDA antagonist, APV blocks LTP in these areas. This receptor has also been linked to neuronal development and it has been implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
Product DetailsProduct Details
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against a fusion protein corresponding to amino acids 75-325 (extracellular, N-terminus) of rat GluN2A/NR2A glutamate receptor protein.
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
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WB - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
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This antibody is effective in immunoblotting (WB).
- Product Citations
-
- RRID
-
AB_2564953 (BioLegend Cat. No. 832102)
AB_2564953 (BioLegend Cat. No. 832101)
Antigen Details
- Structure
- Expected MW: 170 kD
- Cell Type
- Glutamatergic Neurons
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Postsynaptic proteins
- Gene ID
- 24409 View all products for this Gene ID
- Specificity (DOES NOT SHOW ON TDS):
- NMDAR2A
- Specificity Alt (DOES NOT SHOW ON TDS):
- NMDAR2A
- App Abbreviation (DOES NOT SHOW ON TDS):
- WB
- UniProt
- View information about NMDAR2A on UniProt.org
Related FAQs
Other Formats
View All NMDAR2A Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-NMDAR2A | N327/95 | WB |
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-NMDAR2A
Western blot of purified anti-NMDAR2A antibody (clone N327/9...
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