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APC anti-human CD166 Antibody

Pricing & Availability
Clone
A17193B (See other available formats)
Regulatory Status
RUO
Other Names
CD6 ligand, Activated Leukocyte Cell Adhesion Molecule (ALCAM)
Isotype
Mouse IgG2b, κ
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Product Citations
publications
A17193B_APC_CD166_Antibody_082123
Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD166 (clone A17193B) APC (left) or mouse IgG2b, κ APC isotype control (right).
  • A17193B_APC_CD166_Antibody_082123
    Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and anti-human CD166 (clone A17193B) APC (left) or mouse IgG2b, κ APC isotype control (right).
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381905 25 tests 132€
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Description

CD166, also known as the CD6 ligand or the Activated Leukocyte Cell Adhesion Molecule (ALCAM), is a 100-105 kD transmembrane glycoprotein. It belongs to the Ig superfamily of proteins and expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently, CD166 has also been used as a potential cancer stem cell marker.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human CD166 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_3083198 (BioLegend Cat. No. 381905)

Antigen Details

Structure
Type I transmembrane glycoprotein belonging to the Ig superfamily of proteins
Distribution

CD166 is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons

Function
Play an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development
Ligand/Receptor
CD6
Cell Type
Granulocytes, Monocytes, T cells
Biology Area
Cell Adhesion, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Aruffo A, et al. 1997. Immunol Today. 18:498-504.
  2. Bowen MA, et al. 1995. J Exp Med. 181:2213-20.
  3. Patel DD, et al. 1995. J Exp Med. 181:1563-8.
  4. Horst D, et al. 2009. Cancer Invest. 27:844-50.
Gene ID
214 View all products for this Gene ID
UniProt
View information about CD166 on UniProt.org
Go To Top Version: 1    Revision Date: 08.21.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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