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APC anti-human CD185 (CXCR5) Recombinant Antibody

Pricing & Availability
Clone
QA21A13 (See other available formats)
Regulatory Status
RUO
Other Names
BLR1, MDR15
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA21A13_APC_CD185_Antibody_1_121323
Human peripheral blood lymphocytes were stained with anti-human CD19 FITC and anti-human CD185 (CXCR5) recombinant (clone QA21A13) APC (left) or mouse IgG1, κ APC isotype control (right).
  • QA21A13_APC_CD185_Antibody_1_121323
    Human peripheral blood lymphocytes were stained with anti-human CD19 FITC and anti-human CD185 (CXCR5) recombinant (clone QA21A13) APC (left) or mouse IgG1, κ APC isotype control (right).
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382403 25 tests 116€
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382404 100 tests 296€
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Description

CD185, also known as CXCR5, is a 42 kD G-protein coupled receptor with seven transmembrane regions. CXCR5 is expressed by mature B cells, follicular helper T cells, Burkitt’s lymphoma cells and a subset of neurons, and mediates cell migration to the B cell follicles in the secondary lymphoid organs. The ligand of CXCR5 is CXCL13 (BLC).

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone QA21A13 can completely block the binding of clone J252D4 on target cells.

RRID
AB_3097284 (BioLegend Cat. No. 382403)
AB_3097284 (BioLegend Cat. No. 382404)

Antigen Details

Structure
G-protein coupled receptor, 7 transmembrane regions, 42 kD
Distribution

Mature B cells, Follicular helper T cells, and Burkitt's lymphoma cells.

Function
Mediates cell migration to the B cell follicles in the secondary lymphoid organs
Ligand/Receptor
CXCL13
Cell Type
B cells, Tfh
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References
  1. Ma CS, et al. 2012. J Exp Med. 209:1241-53.
  2. León B, et al. 2012. Nat. Immunol. 13:681-90.
  3. Crotty S. 2011. Annu Rev Immunol. 29:621-63.
  4. Kerfoot SM, et al. 2011. Immunity. 34:947-60.
  5. Sáez de Guinoa J, et al. 2011. Blood. 118:1560-9.
Gene ID
643 View all products for this Gene ID
UniProt
View information about CD185 on UniProt.org
Go To Top Version: 1    Revision Date: 12.13.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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