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APC anti-human LGR5 (GPR49) Antibody

Pricing & Availability
Clone
SA222C5 (See other available formats)
Regulatory Status
RUO
Other Names
G-Protein coupled receptor 49 (GPR49), G-Protein coupled receptor 67 (GPR67), FEX, HG38
Isotype
Mouse IgG2a, κ
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Product Citations
publications
SA222C5_APC_LGR5_Antibody_1_112921
Human LGR5 transfected Ba/F3 cells were stained with anti-human LGR5 (clone SA222C5) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
  • SA222C5_APC_LGR5_Antibody_1_112921
    Human LGR5 transfected Ba/F3 cells were stained with anti-human LGR5 (clone SA222C5) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
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373805 25 tests 157€
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373806 100 tests 328€
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Description

LGR5, also known as GPR49, is a 100 KD protein. It is a member of GPCR class A orphan receptor proteins which binds R-spondin and does not activate through heterotrimeric G protein like other GPCR. It triggers the Wnt signaling pathway downstream. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human LGR5 transfectant cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

 

 

Excitation Laser
Red Laser (633 nm)
RRID
AB_2904406 (BioLegend Cat. No. 373805)
AB_2904406 (BioLegend Cat. No. 373806)

Antigen Details

Structure
G-protein coupled receptor (GPCR) superfamily
Distribution

Muscle, placenta, spinal cord, brain and particularly as a biomarker of adult stem cells in certain tissues.

Function
Triggers Wnt signaling pathway.
Interaction
Wnt pathway
Ligand/Receptor
R-spondins (RSpo 1,2,3, and 4)
Biology Area
Immunology
Antigen References

1. Hsu Sy, et al. 1998. Mol. Endocrinol. 12:1830.
2. Barker N, et al. 2007. Nature. 449:1003.
3. Morita H, et al. 2004. Mol. Cell. Biol. 24(22):9736.
4. Arioka Y, et al. 2017. Stem Cell Res. 20:1.
5. Wang B, et al. 2016. Plos. One. 11:e0168904.
6. Garcia MI, et al. 2009. Dev. Biol. 331:58.

Gene ID
8549 View all products for this Gene ID
UniProt
View information about LGR5 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.24.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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