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APC anti-mouse CD45 Antibody

Pricing & Availability
Clone
30-F11 (See other available formats)
Regulatory Status
RUO
Other Names
T200, Ly-5, LCA
Isotype
Rat IgG2b, κ
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Product Citations
publications
30-F11_APC_090507
C57BL/6 mouse splenocytes stained with 30-F11 APC
  • 30-F11_APC_090507
    C57BL/6 mouse splenocytes stained with 30-F11 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
103111 25 µg 27€
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103112 100 µg 76€
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Description

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from variable splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse thymus or spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone 30-F11 reacts with all isoforms and both CD45.1 and CD45.2 alloantigens of CD45.

Additional reported applications (for relevant formats) include: immunoprecipitation3, complement-dependent cytotoxicity1,5, immunohistochemistry (acetone-fixed frozen sections, zinc-fixed paraffin-embedded sections and formalin-fixed paraffin-embedded sections)4,6, Western blotting7, and spatial biology (IBEX)10,11. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103163 and 103164).

Application References

(PubMed link indicates BioLegend citation)
  1. Podd BS, et al. 2006. J. Immunol. 176:6532. (FC, CMCD) PubMed
  2. Haynes NM, et al. 2007. J. Immunol. 179:5099. (FC)
  3. Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IP)
  4. Simon DI, et al. 2000. J. Clin. Invest. 105:293. (IHC)
  5. Seaman WE. 1983. J. Immunol. 130:1713. (CMCD)
  6. Cornet A, et al. 2001. P. Natl. Acad. Sci. USA 98:13306. (IHC)
  7. Tsuboi S and Fukuda M. 1998. J. Biol. Chem. 273:30680. (WB) PubMed
  8. Liu F, et al. 2012. Blood. 119:3295. PubMed
  9. Pelletier AN, et al. 2012. J. Immunol. 188:5561. PubMed
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Gavin KM, et al. 2018. Front Endocrinol (Lausanne). 9:276. PubMed
  2. Wang L, et al. 2018. Bone Res. 6:22. PubMed
  3. Cha JH et al. 2018. Molecular cell. 71(4):606-620 . PubMed
  4. Haimon Z et al. 2018. Nature immunology. 19(6):636-644 . PubMed
  5. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  6. Strickley JD, et al. 2019. Nature. 575:519. PubMed
  7. Jiang Z, et al. 2021. J Clin Invest. 131: . PubMed
  8. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  9. Shah D, et al. 2021. Oncoimmunology. 10:1939601. PubMed
  10. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  11. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  12. Yang D, et al. 2022. Cell. 185:1905. PubMed
  13. Witherel CE, et al. 2021. Biomaterials. 269:120667. PubMed
  14. Kozuki S, et al. 2022. Genes Cells. 27:192. PubMed
  15. Cautivo KM, et al. 2022. Immunity. 55:254. PubMed
  16. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  17. Lloyd-Lewis B, et al. 2022. Cell Rep. 38:110461. PubMed
  18. Yang Y, et al. 2022. FEBS J. 289:5279. PubMed
  19. MacLean AJ, et al. 2022. Immunity. 55:718. PubMed
  20. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  21. Van Deren DA, et al. 2022. Development. 149: . PubMed
  22. Lee R, et al. 2022. Cancer Discov. 12:1702. PubMed
  23. Jiang W, et al. 2022. FASEB J. 36:e22294. PubMed
  24. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  25. Wu TJ, et al. 2022. Cell Mol Life Sci. 79:348. PubMed
  26. Malhi H, et al. 2022. Cell Rep Med. 3:100658. PubMed
  27. Campisi L, et al. 2022. Nature. 606:945. PubMed
  28. Ma Z, et al. 2022. Theranostics. 12:4965. PubMed
  29. Richards M, et al. 2022. Elife. 11: . PubMed
  30. Gao Y, et al. 2022. Cell Res. 32:1086. PubMed
  31. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  32. Liang Y, et al. 2022. Theranostics. 12:7729. PubMed
  33. Cattaneo P, et al. 2022. Nat Commun. 13:7444. PubMed
  34. Wang H, et al. 2022. J Nanobiotechnology. 20:513. PubMed
  35. Kuo CS, et al. 2022. Elife. 11: . PubMed
  36. Ge Y, et al. 2022. STAR Protoc. 4:101936. PubMed
  37. Yu J, et al. 2022. Nat Commun. 13:7903. PubMed
  38. Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed
  39. Al-Saafeen BH, et al. 2023. Front Immunol. 13:1017780. PubMed
  40. Hu R, et al. 2023. Cell Death Discov. 9:50. PubMed
  41. Wang L, et al. 2023. Oxid Med Cell Longev. 2023:6480848. PubMed
  42. Dragan M, et al. 2022. J Invest Dermatol. 142:583. PubMed
  43. Wei J, et al. 2022. Cancer Prev Res (Phila). 15:285. PubMed
  44. Yang Z, et al. 2022. J Nucl Med. 63:1708. PubMed
  45. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  46. Li DD, et al. 2022. Cell Host Microbe. 30:530. PubMed
  47. Tan L, et al. 2022. Aging Dis. 13:1562. PubMed
  48. Bohrer AC, et al. 2022. Cell Rep. 40:111144. PubMed
  49. Yu L, et al. 2022. Cancer Sci. 113:3980. PubMed
  50. Kuo A, et al. 2022. Elife. 11:. PubMed
  51. Chen LC, et al. 2023. Immunology. 169:271. PubMed
  52. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  53. Peng YJ, et al. 2023. Development. 150:. PubMed
  54. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  55. Pioli KT, et al. 2023. iScience. 26:106223. PubMed
  56. Wu Y, et al. 2023. Nat Cancer. 4:382. PubMed
  57. Henn RE, et al. 2023. iScience. 26:106164. PubMed
  58. Barberio AE, et al. 2023. Bioeng Transl Med. 8:e10453. PubMed
  59. Kawai H, et al. 2023. JBMR Plus. 7:e10722. PubMed
  60. Tan X, et al. 2023. Adv Sci (Weinh). 10:e2206768. PubMed
  61. Palakurthi B, et al. 2023. Nat Commun. 14:2109. PubMed
  62. Yao H, et al. 2023. Front Immunol. 14:1147674. PubMed
  63. Hernandez VG, et al. 2023. Glia. 71:1960. PubMed
  64. Liu H, et al. 2023. Breast Cancer Res. 25:43. PubMed
  65. Petenkova A, et al. 2023. Nat Commun. 14:2761. PubMed
  66. Abdelwahab T, et al. 2023. iScience. 26:106698. PubMed
  67. Shao X, et al. 2023. Cell Discov. 9:44. PubMed
  68. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  69. Kalgudde Gopal S, et al. 2023. Nat Commun. 14:3020. PubMed
  70. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  71. Bouchareychas L, et al. 2021. iScience. 24(8):102847. PubMed
  72. Almada AE, et al. 2021. Cell Reports. 34(4):108656. PubMed
  73. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  74. Garcia-Fabiani MB, et al. 2020. Methods Enzymol. 632:369. PubMed
  75. Jaiswal AK, et al. 2020. Immunobiology. 225:151956. PubMed
  76. Cayre S, et al. 2020. Development. 147:00:00. PubMed
  77. Díaz NM, et al. 2020. Invest Ophthalmol Vis Sci. 61:37:00. PubMed
  78. Mourao L, et al. 2019. Sci Rep. 0.991666667. PubMed
  79. Oetjen LK et al. 2017. Cell. 171(1):217-228 . PubMed
  80. Testini C, et al. 2019. EMBO Rep. 20:e47845. PubMed
  81. Gao Q, et al. 2019. J Exp Med. 216:688. PubMed
  82. Shavit Stein E, et al. 2018. Neural Plast. 2018:7692182. PubMed
  83. Ahmed M, et al. 2016. Development. 143: 1663 - 1673. PubMed
  84. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  85. Lim JT, et al. 2020. Mol Cancer Ther. 1809:19. PubMed
  86. Karlen SJ, et al. 2018. J Neuroinflammation. 15:344. PubMed
  87. Du Q, et al. 2019. Front Microbiol. 10:2050. PubMed
  88. Kang I, et al. 2012. Blood. 119:3295. PubMed
  89. Rosa FF, et al. 2020. Bio Protoc. 10:e3619. PubMed
  90. Wang Y, et al. 2021. J Bone Oncol. 30:100386. PubMed
  91. Lu L, et al. 2022. Sci Rep. 12:931. PubMed
  92. Parhiz H, et al. 2022. J Control Release. 344:50. PubMed
  93. Yanagida K, et al. 2020. Dev Cell. 779:52. PubMed
  94. Hirano KI, et al. 2021. eLife. 0.416666666666667. PubMed
  95. Larouche JA, et al. 2021. eLife. 0.416666666666667. PubMed
  96. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  97. Barberio AE, et al. 2020. ACS Nano. 14:11238. PubMed
  98. Chiche A, et al. 2016. Oncogene. 10.1038/onc.2016.396. PubMed
  99. Eastman A, et al. 2016. J Immunol . 194: 5999-6010. PubMed
  100. Engelbrecht E, et al. 2020. eLife. 9:e52690.. PubMed
  101. Hays C, et al. 2020. eLife. 8:e48772.. PubMed
  102. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  103. Chen J, et al. 2022. Nat Commun. 13:6759. PubMed
  104. Wang S, et al. 2022. Front Immunol. 13:869061. PubMed
  105. Zhang Y, et al. 2022. Cancers (Basel). 14:. PubMed
  106. Barwe SP, et al. 2022. J Clin Med. 11:. PubMed
  107. Tilstam PV, et al. 2021. J Clin Invest. 131:. PubMed
  108. Yu X, et al. 2021. Nature. 594:560. PubMed
  109. Sato S, et al. 2021. Int J Mol Sci. 22:. PubMed
  110. Oliva Chávez AS, et al. 2021. Nat Commun. 12:3696. PubMed
  111. Strunz M, et al. 2020. Nat Commun. 2.929861111. PubMed
  112. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  113. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  114. Wosczyna MN, et al. 2021. Cell Stem Cell. 28(7):1323-1334.e8. PubMed
  115. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  116. Zhao B, et al. 2021. Cell Reports. 36(3):109401. PubMed
  117. Motoyama S, et al. 2020. Cells. :9. PubMed
  118. Jin X, et al. 2019. Mol Cell. 73:22:00. PubMed
  119. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  120. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  121. Romagnoli M, et al. 2020. Development. 147:. PubMed
  122. Li Q, et al. 2021. Brain Behav Immun. 94:437. PubMed
  123. Wang X, et al. 2022. Nat Aging. 2:155. PubMed
  124. Wang T, et al. 2020. Blood Sci. 2:79. PubMed
  125. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  126. Amouyal C, et al. 2020. EBioMedicine. 58:102895. PubMed
  127. Liu L, et al. 2015. Neurol Neuroimmunol Neuroinflamm. 2: 174. PubMed
  128. Hyatt L, et al. 2014. PLoS One. 9:109072. PubMed
  129. Pelletier A, et al. 2012. J Immunol. 188:5561. PubMed
  130. Herting CJ, et al. 2019. Brain. 142:3834. PubMed
  131. Romagnoli M, et al. 2019. Stem Cell Reports. 1.077083333. PubMed
  132. Ning X, et al. 2019. Mol Cell. 74:19. PubMed
  133. De S, et al. 2018. Development. 145. PubMed
  134. Xiao X, et al. 2019. Cell Discov. 5:2. PubMed
  135. Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed
  136. Chen Z, et al. 2022. Theranostics. 12:6242. PubMed
  137. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  138. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  139. Khateb M, et al. 2022. Cell Rep. 40:111219. PubMed
  140. Xu Q, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  141. Liu K, et al. 2022. Theranostics. 12:639. PubMed
  142. Sato Y, et al. 2021. J Clin Invest. Online ahead of print. PubMed
  143. Lafkas D, et al. 2013. J Cell Biol. 203:47. PubMed
  144. Ma S, et al. 2021. Cell Reports. 34(6):108726. PubMed
  145. Ankawa R, et al. 2021. Developmental Cell. . PubMed
  146. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  147. Wosczyna MN et al. 2019. Cell Rep. 27(7):2029-2035 . PubMed
  148. Maston LD, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L609. PubMed
  149. Bresson L, et al. 2018. Development. 145. PubMed
  150. Charmsaz S, et al. 2017. Leukemia. 31:1779. PubMed
  151. Sambasivan R, et al. 2011. Development. 138:3647. PubMed
  152. Hu EY, et al. 2021. Blood Adv. 5:3152. PubMed
  153. Palathingal Bava E, et al. 2022. JCI Insight. 7:. PubMed
  154. Shcherbina A, et al. 2020. Cell Rep. 32:107964. PubMed
  155. Wu J, et al. 2020. Immunity. 53:115. PubMed
  156. Frii J, et al. 2021. Immunity. 54(5):1002-1021.e10. PubMed
  157. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  158. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  159. Xiao P, et al. 2019. J Exp Med. 216:337. PubMed
  160. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  161. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  162. Zheng B, et al. 2018. J Hematol Oncol. 11:16. PubMed
  163. Pal B, et al. 2017. Nat Commun.. 10.1038/s41467-017-01560-x. PubMed
  164. Fischer A, et al. 2022. Nat Immunol. 23:518. PubMed
  165. Hu J, et al. 2022. Cell Mol Neurobiol. . PubMed
  166. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  167. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  168. Yuan Z, et al. 2018. Emerg Microbes Infect. 7:59. PubMed
  169. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  170. Morimoto A, et al. 2021. Nat Commun. 12:2136. PubMed
  171. Hanasoge Somasundara AV, et al. 2021. Cell Rep. 37:110099. PubMed
  172. Thinard R, et al. 2022. Pharmaceutics. 14:. PubMed
  173. Yang H, et al. 2022. Nutrients. 14:. PubMed
  174. Hu J, et al. 2022. J Neuroinflammation. 19:71. PubMed
  175. Pezoldt J, et al. 2022. Nat Commun. 13:7227. PubMed
  176. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  177. Paiva-Oliveira E, et al. 2017. Histochem Cell Biol. 10.1007/s00418-017-1556-6. PubMed
  178. Dudek KA, et al. 2020. Proc Natl Acad Sci U S A. 117:3326. PubMed
  179. Bradley KC, et al. 2019. Cell Rep. 28:245. PubMed
  180. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  181. Yang J, et al. 2022. Microbiome. 10:149. PubMed
  182. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  183. Koren E, et al. 2022. Nat Commun. 13:4628. PubMed
  184. Bauer T, et al. 2021. Life (Basel). 11:. PubMed
  185. Li P, et al. 2022. EMBO Mol Med. 14:e14511. PubMed
  186. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  187. Myerson JW, et al. 2021. Nat Nanotechnol. Online ahead of print. PubMed
  188. Wang C, et al. 2011. Hepatology. 55:108. PubMed
  189. Sim S, et al. 2016. PLoS One. 11: 0152485. PubMed
  190. Mangum L, et al. 2016. Toxicol Sci. 150: 169 - 177. PubMed
  191. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  192. Nosho S, et al. 2020. Int J Mol Sci. 21:00. PubMed
  193. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  194. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  195. Liu S, et al. 2020. Cell Host & Microbe. 26(6):779-794.e8.. PubMed
  196. Zhou G, et al. 2019. FASEB J. 33:11396. PubMed
  197. Shannon JP, et al. 2021. STAR Protoc. 2:100790. PubMed
  198. Yang Y, et al. 2022. Elife. 11:. PubMed
  199. Dey S, et al. 2020. J Immunother Cancer. 8:. PubMed
  200. Zhang Q, et al. 2022. Nat Commun. 13:2406. PubMed
  201. Scur M, et al. 2022. Nat Commun. 13:7272. PubMed
  202. Xi W, et al. 2021. Stem Cell Res Ther. 167:12. PubMed
  203. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  204. Dawson CA, et al. 2021. Nature Protocols. 16(4):1907-1935. PubMed
  205. Seki T, et al. 2015. J Biochem. 158: 485 - 495. PubMed
  206. Yamada KJ, et al. 2020. PLoS Pathog. 16:e1008354. PubMed
  207. Tu WL, et al. 2018. Am J Pathol. 188:2688. PubMed
  208. Chiche A, et al. 2019. Breast Cancer Res. 21:13. PubMed
  209. Feng J,et al. 2017. Nat Commun. . 10.1038/s41467-017-01056-8. PubMed
  210. Limbad C, et al. 2022. iScience. 25:103848. PubMed
  211. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  212. Aguilera M, et al. 2021. Int J Mol Sci. 22:. PubMed
  213. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  214. Ding X, et al. 2015. J Immunol. 194:4251. PubMed
  215. Wang L, et al. 2015. Cancer Immunol Res. 3: 1030-1041. PubMed
  216. Mueller A, et al. 2016. Nature. 540:276-279. PubMed
  217. Perry JL, et al. 2020. ACS Nano. 5.583333333. PubMed
  218. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  219. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  220. Mori A, et al. 2021. Cells. :10. PubMed
  221. Echevarría-Vargas IM, et al. 2018. EMBO Mol Med. 10:e8446. PubMed
  222. Shi R, et al. 2019. J Cancer. 10:367. PubMed
  223. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  224. Usmani SM et al. 2019. Cell host & microbe. 25(1):73-86 . PubMed
  225. Zasłona Z, et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312:L855. PubMed
  226. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  227. Liu D, et al. 2020. Front Pharmacol. 11:204. PubMed
  228. Dion-Albert L, et al. 2022. Nat Commun. 13:164. PubMed
  229. Long JT, et al. 2022. Elife. 11:. PubMed
  230. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  231. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  232. Yang Y, et al. 2021. Cell Reports. 34(10):108822. PubMed
  233. Taya M, et al. 2020. Endocr Relat Cancer. 27:261. PubMed
  234. Cai B, et al. 2020. Cell Metabolism. 31(2):406-421.e7.. PubMed
  235. Lu Y, et al. 2020. Immunity. 52:782. PubMed
  236. Toyama K, et al. 2018. Arterioscler Thromb Vasc Biol. 38:1392. PubMed
  237. Qiao S, et al. 2019. J Neuroinflammation. 16:4. PubMed
  238. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  239. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  240. Murdock BJ, et al. 2021. JCI Insight. 6:. PubMed
  241. Elias S, et al. 2015. PLoS Biol. 13:1002142. PubMed
  242. Deng P, et al. 2021. Cell Stem Cell. 28(6):1057-1073.e7. PubMed
  243. Zhang Y, et al. 2020. Cancer Res. 80:3345. PubMed
  244. Carmody C et al. 2019. Endocrinology. 160(5):1205-1222 . PubMed
  245. Fu NY, et al. 2018. Dev Cell. 47:629. PubMed
  246. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  247. Yeo SK, et al. 2020. eLife. 9:e58810.. PubMed
  248. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  249. Hoover AR, et al. 2022. Clin Transl Med. 12:e937. PubMed
  250. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  251. Nasser H, et al. 2020. Cell Death Discov. 0.29375. PubMed
  252. Sroor HM, et al. 2019. Sci Rep. 9:20217. PubMed
  253. Chen PY, et al. 2019. Nat Metab. 0.675. PubMed
  254. Cao Y, et al. 2019. Nat Commun. 10:1280. PubMed
  255. Liu L et al. 2018. Cell stem cell. 23(4):544-556 . PubMed
  256. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  257. Zhang T, et al. 2020. JCI Insight. 5:00. PubMed
  258. Porrello A, et al. 2018. Nat Commun. 9:1988. PubMed
  259. Cai T, et al. 2022. Nat Commun. 13:2228. PubMed
  260. Kim KS, et al. 2022. JCI Insight. 7:. PubMed
  261. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  262. Vaas M, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16676825. PubMed
  263. Wong J, et al. 2016. Sci Signal. 9: ra103. PubMed
  264. Yuan Z, et al. 2016. J Virol. 90: 7728 - 7739. PubMed
  265. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  266. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  267. Roberts L, et al. 2014. Infect Immun . 82:2504. PubMed
  268. Ortiz A, et al. 2019. Cancer Cell. 35:33:00. PubMed
  269. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  270. Piotrowski AF, et al. 2018. Oncoimmunology. 7:e1445951. PubMed
  271. Sarshad AA, et al. 2018. Mol Cell. 71:1040. PubMed
  272. Liu G, et al. 2022. Theranostics. 12:2248. PubMed
  273. Piirainen S, et al. 2021. Glia. 69:2459. PubMed
  274. Arora S, et al. 2021. Med (N Y). 2:938. PubMed
  275. Li H, et al. 2022. iScience. 25:104481. PubMed
  276. Cayre S, et al. 2020. Development. . PubMed
  277. Endo-Umeda K, et al. 2021. Sci Rep. 11:22595. PubMed
  278. Pal B, et al. 2021. Breast Cancer Res. 23:69. PubMed
  279. Maller O, et al. 2020. Nat Mater. 20:548. PubMed
  280. Gopalakrishnapillai A, et al. 2021. Cancers (Basel). 13:. PubMed
  281. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  282. Koh BI, et al. 2020. Nat Commun. 3.143055556. PubMed
  283. Ren D, et al. 2020. Am J Cancer Res. 2851:10. PubMed
  284. Su M, et al. 2018. Immunol Cell Biol. 9:2448. PubMed
  285. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  286. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  287. Qu Y, et al. 2020. Cell Reports. 32(1):107873. PubMed
  288. Hu Y, et al. 2021. J Nanobiotechnology. 19:416. PubMed
  289. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  290. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  291. Bravo JI, et al. 2021. STAR Protocols. 2(2):100406. PubMed
  292. Chng S, et al. 2016. Sci Rep. 6: 23820. PubMed
  293. Kabir AU, et al. 2018. JCI Insight. 3. PubMed
  294. Quijano-Rubio A, et al. 2022. Nat Biotechnol. Online ahead of print. PubMed
  295. Scheyltjens I, et al. 2022. Nat Protoc. 17:2354. PubMed
  296. Liu C, et al. 2022. Nat Commun. 13:1989. PubMed
  297. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  298. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  299. Okubo A, et al. 2021. Int J Mol Sci. 23:. PubMed
  300. Deets KA, et al. 2021. Elife. 10:. PubMed
  301. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  302. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  303. Zhong J, et al. 2021. Commun Biol. 4:865. PubMed
  304. Xie Z, et al. 2020. Light Sci Appl. 9:161. PubMed
RRID
AB_312976 (BioLegend Cat. No. 103111)
AB_312976 (BioLegend Cat. No. 103112)

Antigen Details

Structure
Protein tyrosine phosphatase (PTP) family, 180-240 kD
Distribution

All hematopoietic cells except mature erythrocytes and platelets

Function
Phosphatase, T and B cell activation
Ligand/Receptor
Galectin-1, CD2, CD3, CD4, TCR, CD22, Thy-1
Cell Type
B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Trowbridge IS, et al. 1993. Annu. Rev. Immunol. 12:85.
3. Kishihara K, et al. 1993. Cell 74:143.
4. Pulido R, et al. 1988. J. Immunol. 140:3851.

Gene ID
19264 View all products for this Gene ID
UniProt
View information about CD45 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD45 Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse CD45 30-F11 FC
Biotin anti-mouse CD45 30-F11 FC
FITC anti-mouse CD45 30-F11 FC
PE anti-mouse CD45 30-F11 FC
PE/Cyanine5 anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 30-F11 FC,IHC-F,CyTOF®,IP,CMCD,IHC,WB
PE/Cyanine7 anti-mouse CD45 30-F11 FC
APC/Cyanine7 anti-mouse CD45 30-F11 FC
Alexa Fluor® 488 anti-mouse CD45 30-F11 FC,SB
Alexa Fluor® 647 anti-mouse CD45 30-F11 FC,ICC,IHC,3D IHC,SB
Pacific Blue™ anti-mouse CD45 30-F11 FC
Alexa Fluor® 700 anti-mouse CD45 30-F11 FC,SB
PerCP/Cyanine5.5 anti-mouse CD45 30-F11 FC
PerCP anti-mouse CD45 30-F11 FC
Alexa Fluor® 594 anti-mouse CD45 30-F11 IHC-F,FC,3D IHC
Brilliant Violet 421™ anti-mouse CD45 30-F11 FC,SB
Brilliant Violet 570™ anti-mouse CD45 30-F11 FC
Brilliant Violet 510™ anti-mouse CD45 30-F11 FC
Brilliant Violet 605™ anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 (Maxpar® Ready) 30-F11 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse CD45 30-F11 FC
Brilliant Violet 711™ anti-mouse CD45 30-F11 FC
Brilliant Violet 785™ anti-mouse CD45 30-F11 FC
Brilliant Violet 650™ anti-mouse CD45 30-F11 FC
APC/Fire™ 750 anti-mouse CD45 30-F11 FC
Brilliant Violet 750™ anti-mouse CD45 30-F11 FC
TotalSeq™-A0096 anti-mouse CD45 30-F11 PG
TotalSeq™-B0096 anti-mouse CD45 30-F11 PG
Ultra-LEAF™ Purified anti-mouse CD45 30-F11 FC,CyTOF®,IP,CMCD,IHC,WB
Spark Blue™ 550 anti-mouse CD45 30-F11 FC
Spark NIR™ 685 anti-mouse CD45 30-F11 FC
TotalSeq™-C0096 anti-mouse CD45 30-F11 PG
Spark YG™ 570 anti-mouse CD45 30-F11 IHC-F
PE/Fire™ 640 anti-mouse CD45 30-F11 FC
APC/Fire™ 810 anti-mouse CD45 30-F11 FC
PE/Fire™ 700 anti-mouse CD45 30-F11 FC
Spark Violet™ 538 anti-mouse CD45 30-F11 FC
Spark YG™ 593 anti-mouse CD45 30-F11 FC
Spark Blue™ 574 anti-mouse CD45 Antibody 30-F11 FC
Spark Blue™ 515 anti-mouse CD45 30-F11 FC
Spark UV™ 387 anti-mouse CD45 30-F11 FC
PE/Fire™ 810 anti-mouse CD45 30-F11 FC
Spark Red™ 718 anti-mouse CD45 (Flexi-Fluor™) 30-F11 FC
Spark PLUS UV395™ anti-mouse CD45 30-F11 FC
Go To Top Version: 2    Revision Date: 05.14.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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