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APC anti-mouse Podoplanin Antibody

Pricing & Availability
Clone
8.1.1 (See other available formats)
Regulatory Status
RUO
Other Names
T1a, gp38, stromal cell marker
Isotype
Syrian Hamster IgG
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Product Citations
publications
8.1.1_APC_060710
Mouse thymic epithelial stromal cell line TE-71 stained with 8.1.1 APC
  • 8.1.1_APC_060710
    Mouse thymic epithelial stromal cell line TE-71 stained with 8.1.1 APC
Compare all formats See APC spectral data
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127409 25 µg 110€
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127410 100 µg 243€
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Description

The mucin-type glycoprotein podoplanin is thought to be involved in the development of the lymphatic vascular system. Podoplanin is named after its expression in the kidney glomerular epithelial cells (podocytes). It has a potential role in tumor progression.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Syrian Hamster
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemistry6, and spatial biology (IBEX)8,9.

Application References

(PubMed link indicates BioLegend citation)
  1. Farr A, et al. 1992. J. Histochem. Cytochem. 40:651.
  2. Farr AG, et al. 1992. J. Exp. Med. 176:1477.
  3. Bekiaris V, et al. 2008. J. Immunol. 180:6768.
  4. Algars A, et al. 2011. Blood 117:4387. PubMed
  5. Reis VO, et al. 2012. Immunobiology. 217:831. PubMed
  6. Kaji C, et al. 2012. Acta. Histochem. Cytochem. 45:227. (IHC)
  7. Kretschmer S, et al. 2013. PLoS One. 8:e52201. PubMed.
  8. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  9. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  2. Buechler MB, et al. 2021. Nature. 593:575. PubMed
  3. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  4. Garnier L, et al. 2022. Sci Adv. 8:eabl5162. PubMed
  5. Jiang W, et al. 2022. Redox Biol. 56:102432. PubMed
  6. Krishnamurty AT, et al. 2022. Nature. 611:148. PubMed
  7. Tomiaki C, et al. 2022. Front Immunol. 13:1014462. PubMed
  8. Sastourné-Arrey Q, et al. 2023. Nat Commun. 14:80. PubMed
  9. Cheong LY, et al. 2023. Nat Commun. 14:1213. PubMed
  10. Urban SK, et al. 2020. Liver Int. 40:3103. PubMed
  11. Weeden C, et al. 2017. PLoS Biol. 10.1371/journal.pbio.2000731. PubMed
  12. McCarthy N, et al. 2020. Cell Stem Cell. 391:26. PubMed
  13. Rodda LB et al. 2018. Immunity. 48(5):1014-1028 . PubMed
  14. Schwab M, et al. 2021. Exp Dermatol. 30:1619. PubMed
  15. Seidenberg J, et al. 2021. Int J Mol Sci. :22. PubMed
  16. Brinkman C, et al. 2013. J Immunol. 191:2412. PubMed
  17. Davidson S, et al. 2020. Cell Reports. 31(7):107628. PubMed
  18. Duan L, et al. 2021. Immunity. 54:2256. PubMed
  19. Jackson-Jones LH, et al. 2020. Immunity. 52:700. PubMed
  20. Donati Y, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L619:318. PubMed
  21. Clement CC, et al. 2021. Nat Commun. 12:4447. PubMed
  22. Walsh SM, et al. 2021. eLife. 10:00. PubMed
  23. Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed
  24. Matthew B Buechler et al. 2019. Immunity. 51(1):119-130 . PubMed
  25. Denton A, et al. 2014. Proc Natl Acad Sci U S A. 111:12139. PubMed
  26. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  27. Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed
  28. Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
  29. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  30. Blaskovic S, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L606:318. PubMed
  31. Coulombe P et al. 2019. Cell reports. 27(6):1769-1780 . PubMed
  32. Kurashima Y, et al. 2021. Nat Commun. 12:1067. PubMed
  33. Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed
  34. Hirota K et al. 2018. Immunity. 48(6):1220-1232 . PubMed
  35. Tadayon S, et al. 2021. Front Immunol. 12:602122. PubMed
  36. Costa B, et al. 2019. Blood Adv. 3:1092. PubMed
RRID
AB_10612940 (BioLegend Cat. No. 127409)
AB_10612940 (BioLegend Cat. No. 127410)

Antigen Details

Structure
43 Kd glycosylated type-1 transmembrane protein. Mucin-type protein.
Distribution

Expressed on epithelial and mesothelial cells.

Cell Type
Epithelial cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Antigen References

1. Farr A, et al. 1992. J. Histochem. Cytochem. 40:651.
2. Schacht V, et al. 2005. Am. J. Pathol. 166:913.

Gene ID
14726 View all products for this Gene ID
UniProt
View information about Podoplanin on UniProt.org
Go To Top Version: 2    Revision Date: 02.03.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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