APC/Fire™ 750 anti-human CD49d, CD49d, 9F10

Pricing & Availability

Analyte Specific Reagent. Analytical and performance characteristics are not established.

Clone: 9F10
Workshop: V S215
Other Names: VLA-4 α chain, α4 integrin, Integrin α4 chain, ITGA4
Isotype: Mouse IgG1, κ

9F10_APC-Fire750_CD49d_ASR_060723 — Typical results from human peripheral blood lymphocytes stained either with 9F10 APC/Fire™ 750 used at 5 μL/test (filled histogram) or with an isotype control (open histogram).

Compare all formats See APC/Fire™ 750 spectral data

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987702

500 µL

301€

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Description

CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation.

Product Details

Technical Data Sheet (pdf)

Product Details

Reactivity: Human
Formulation: Phosphate-buffered solution, pH7.2, containing True-Stain Monocyte Blocker™, 0.09% sodium azide, 0.2% (w/v) BSA (origin USA), and a stabilizer.
Preparation: The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
Concentration: 200 µg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: Suggested for Flow Cytometry

Antigen Details

Antigen References: Elices M, Ed. 1995. Springer Semin. Immunopathol. 16(4).

Lobb RR and Helmer ME. 1994. J. Clin. Invest. 94:1722-8.

Documentation

Certificate of Analysis

Go To Top Version: 1 Revision Date: 06.27.2023

Analyte Specific Reagent. Analytical and performance characteristics are not established.

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