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Biotin anti-human TCR Cβ1 Antibody

Pricing & Availability
Clone
JOVI.1 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor beta constant 1, TRBC1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
JOVI-1_Biotin_TCR-CB1_Antibody_1_052924
Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) APC and biotinylated anti-human TCR Cβ1 (clone JOVI.1) (left) or biotinylated mouse IgG2a, κ isotype control (right), followed by SAV-PE.
  • JOVI-1_Biotin_TCR-CB1_Antibody_1_052924
    Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) APC and biotinylated anti-human TCR Cβ1 (clone JOVI.1) (left) or biotinylated mouse IgG2a, κ isotype control (right), followed by SAV-PE.
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383512 100 µg 272€
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Description

The T cell receptor beta chain constant region-1 (TCR Cβ1), also known as TRBC1, is a segment of the TCR beta chain that forms the constant region of the T cell receptor. The rearrangement of TCR genes during T cell development leads to the selection of one of two TCR beta constant regions – C1 or C2. Detection of TRBC1 within a comprehensive T cell panel can be used as evidence of clonality akin to the use of kappa/lambda light chain detection in the diagnosis of plasma cell malignancies.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Transgenic mouse lymphocytes expressing human Vβ3-Cβ1 TCR
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone JOVI.1 can interfere binding of clone IP26 on target cells.

Application References

(PubMed link indicates BioLegend citation)
  1. Viney, J L et al. 1992. Hybridoma. 11:701-13.
  2. Horna, Pedro et al. 2021. Int J Mol Sci. 22:1817.
RRID
AB_3106255 (BioLegend Cat. No. 383512)

Antigen Details

Structure
Predicted 20 kD Ig-like protein
Distribution

T lymphocytes

Cell Type
Leukemia, Lymphocytes, T cells, Thymocytes
Biology Area
Cancer Biomarkers, Cell Biology, Immunology
Molecular Family
TCRs
Antigen References
  1. Minden, M D and T W Mak. 1986. Blood. 68:327-36.
  2. Davis, M M et al. 1997. Ciba Found Symp. 204:94-100.
  3. Maciocia, Paul M et al. 2017. Nat Med. 23:1416-23.
Gene ID
28639 View all products for this Gene ID
UniProt
View information about TCR Cbeta1 on UniProt.org

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 1    Revision Date: 05.29.2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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