Analyte Specific Reagent. Analytical and performance characteristics are not established.
- Clone
- EBVCS-5
- Other Names
- Leu-20, FcεRII, IgE Fc Receptor, BLAST-2, B6, Low affinity IgE receptor
- Isotype
- Mouse IgG1, κ
-
Typical results from human peripheral blood lymphocytes stained either with EBVC-5-FITC used at 5 μL/test (filled histogram) or with an isotype control (dashed histogram).
Cat # | Size | Price | Quantity Check Availability | Save | ||
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982902 | 500 µL | 194€ |
CD23 is a 45 kD protein, also known as Leu-20, FcεRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region.
Product DetailsProduct Details
- Reactivity
- Human
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Concentration
- 200 µg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
Suggested for Flow Cytometry
- Disclaimer
-
WARNINGS AND PRECAUTIONS
- Use appropriate personal protective equipment and safety practices per universal precautions when working with this reagent. Refer to the reagent safety data sheet.
- This antibody contains sodium azide. Follow federal, state and local regulations to dispose of this reagent. Sodium azide build-up in metal wastepipes may lead to explosive conditions; if disposing of reagent down wastepipes, flush with water after disposal.
- All specimens, samples and any material coming in contact with them should be considered potentially infectious and should be disposed of with proper precautions and in accordance with federal, state and local regulations.
- Do not use this reagent beyond the expiration date stated on the label.
- Do not use this reagent if it appears cloudy or if there is any change in the appearance of the reagent as these may be an indication of possible deterioration.
- Avoid prolonged exposure of the reagent or stained cells to light.
Antigen Details
- Antigen References
-
1. Ludin C, et al. 1987. EMBO J. 6:109.
2. Delespesse G, et al. 1992. Immunol. Rev. 125:77.
3. Flores-Romo L, et al. 1993. Science 261:1038.
4. Armant M, et al. 1994. J. Exp. Med. 180:1005.
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD23
Human peripheral blood lymphocytes stained with purified EBV... -
FITC anti-human CD23
Human peripheral blood lymphocytes stained with CD19 APC and... -
PE anti-human CD23
Human peripheral blood lymphocytes stained with CD19 (HIB19)... -
APC anti-human CD23
Human peripheral blood lymphocytes stained with CD19 PE and ... -
PE/Cyanine7 anti-human CD23
Human peripheral blood lymphocytes stained with CD19 (HIB19)... -
PerCP/Cyanine5.5 anti-human CD23
Human peripheral blood lymphocytes were stained with CD19 AP... -
APC/Cyanine7 anti-human CD23
Human peripheral blood lymphocytes were stained with CD19 PE... -
Brilliant Violet 421™ anti-human CD23
Human peripheral blood lymphocytes were stained with CD19 AP... -
FITC anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
TotalSeq™-A0897 anti-human CD23
-
TotalSeq™-C0897 anti-human CD23
-
TotalSeq™-B0897 anti-human CD23
-
PE anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
PE/Cyanine7 anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
PerCP/Cyanine5.5 anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
TotalSeq™-D0897 anti-human CD23
-
APC anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
GMP FITC anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
GMP APC anti-human CD23
Typical results from human peripheral blood lymphocytes stai... -
Spark YG™ 593 anti-human CD23
Human peripheral blood lymphocytes were surface stained with... -
Spark Violet™ 423 anti-human CD23
Human peripheral blood lymphocytes were stained with anti-hu... -
PE/Fire™ 700 anti-human CD23
Human peripheral blood lymphocytes were stained with anti-hu...
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