- Clone
- 1F8C33 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Msr1, MSR, SR-A, Scavenger receptor type A, Macrophage scavenger receptor I, Scara1
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
154713 | 25 µg | 151€ | ||||
154714 | 100 µg | 344€ |
CD204, also known as scavenger receptor A (SR-A) and the macrophage scavenger receptor (MSR), is 220 kDa, trimeric type II transmembrane protein, with one scavenger receptor cysteine-rich domain (SRCR). It is a phagocytic pattern-recognition receptor (PRR) expressed on macrophages and dendritic cells. CD204 is a receptor mediating recognition and internalization of low-density lipoprotein (LDL) by macrophages and plays a critical role in atherogenesis. CD204 also recognizes apoptotic cells, modified lipid proteins, and exogenous pathogen-associated molecular patterns (PAMPs), which results in the induction of innate immune and inflammatory responses. CD204 can act as a co-receptor for Toll-like receptors, such as TLR3, TLR4, or TLR9, to facilitate the expression of proinflammatory cytokines. CD204 has been implicated in several pathological processes such as Alzheimer’s disease, sepsis, ischemic injury, and coronary artery disease.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD204 extracellular domain
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
This clone has minimal recognition of CD204 in C57BL/6.
- RRID
-
AB_2892312 (BioLegend Cat. No. 154713)
AB_2892312 (BioLegend Cat. No. 154714)
Antigen Details
- Structure
- Trimeric type II transmembrane protein, one scavenger receptor cysteine-rich domain (SRCR), 220 kD.
- Distribution
-
Macrophages, dendritic cells.
- Function
- Uptake of negatively charged molecules, role in pathology of atherosclerosis and Alzheimer’s disease.
- Ligand/Receptor
- Acetylated and oxidized lipoproteins
- Cell Type
- Dendritic cells, Macrophages
- Antigen References
-
- Shichita T, et al. 2017. Nat Med. 23:723.
- Muczynski V, et al. 2017. Blood. 129:2443.
- Iftakhar-E-Khuda I, et al. 2016. Proc Natl Acad Sci U S A. 113:10643.
- Nellimarla S, et al. 2015. J Immunol. 195:3858.
- Bonilla DL, et al. 2013. Immunity. 39:537.
- Gene ID
- 20288 View all products for this Gene ID
- UniProt
- View information about CD204 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All CD204 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse CD204 | 1F8C33 | FC |
TotalSeq™-A0448 anti-mouse CD204 | 1F8C33 | PG |
TotalSeq™-B0448 anti-mouse CD204 (Msr1) | 1F8C33 | PG |
TotalSeq™-C0448 anti-mouse CD204 (Msr1) | 1F8C33 | PG |
PE anti-mouse CD204 | 1F8C33 | FC |
APC anti-mouse CD204 | 1F8C33 | FC |
PE/Cyanine7 anti-mouse CD204 | 1F8C33 | FC |
PerCP/Cyanine5.5 anti-mouse CD204 | 1F8C33 | FC |
PE/Dazzle™ 594 anti-mouse CD204 | 1F8C33 | FC |
Alexa Fluor® 647 anti-mouse CD204 | 1F8C33 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st... -
TotalSeq™-A0448 anti-mouse CD204
-
TotalSeq™-B0448 anti-mouse CD204 (Msr1)
-
TotalSeq™-C0448 anti-mouse CD204 (Msr1)
-
PE anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st... -
APC anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st... -
PE/Cyanine7 anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st... -
PerCP/Cyanine5.5 anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st... -
PE/Dazzle™ 594 anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st... -
Alexa Fluor® 647 anti-mouse CD204
Mouse leukemic monocyte-macrophage cell line RAW267.4 was st...
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