- Clone
- A18231D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Collapsin Response Mediator Protein 5, Dihydropyrimidinase Like 5, DPYSL5, DRP-5, UNC33-Like Phosphoprotein 6, Ulip6
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
614551 | 25 µg | 116€ | ||||
614552 | 100 µg | 332€ |
CRMP5 (Collapsin Response Mediator Protein 5 or DPYSL5) is a member of the CRMP family and is involved in regulation of the cytoskeleton. CRMP5 acts as a negative regulator of microtubule stability and dynamics and participates in the fibroblast growth factor (FGF) signaling pathway, regulating axon guidance and neuronal development. CRMP5 has been implicated in several human diseases. In cancer cells, CRMP5 regulates cancer cell migration, invasion, and proliferation through its interaction with the tumor suppressor protein, PTEN. Mutations in CRMP5 are related to neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorder. CRMP5 regulates tau protein degradation through its interaction with microtubules and enzymes, suggesting its role in neuroinflammation and Alzheimer's disease.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant fragment of CRMP5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
WB - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg/mL is suggested. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This product is not recommended for use in immunocytochemistry (ICC).
For use in immunohistochemistry (IHC), antigen retrieval with Tris-EDTA pH 9.0 is recommended. - RRID
-
AB_2941617 (BioLegend Cat. No. 614551)
AB_2941617 (BioLegend Cat. No. 614552)
Antigen Details
- Structure
- Forms homotetramer and heterotetramer with the other CRMP proteins
- Distribution
-
Cytoplasm; expressed in Neuronal tissue and lung
- Function
- Regulate cytoskeleton stability and dynamics; axon guidance
- Interaction
- Interact with other CRMP proteins, MAP2, TUBB3
- Cell Type
- Mature Neurons, Neural Stem Cells, Neurons
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Neurodegeneration, Neuroinflammation, Neuroscience, Synaptic Biology
- Molecular Family
- APP/Aβ Degradation, Microtubules, Tau
- Antigen References
-
- Yu Z, et al. 2001. Ann Neurol. 49:146-54.
- Bretin S, et al. 2005. J Comp Neurol. 486:1-17.
- Yamashita N, et al. 2011. J Neurosci. 31:1773-9.
- Lin YS, et al. 2019. Neuropharmaology. 157:107673.
- Gene ID
- 56896 View all products for this Gene ID
- UniProt
- View information about CRMP5 on UniProt.org
Other Formats
View All CRMP5 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-CRMP5 | A18231D | IHC-P,WB |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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