- Clone
- O91F4 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GLUL, Glutamine Synthetase
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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856201 | 25 µg | 85€ | ||||
856202 | 100 µg | 221€ |
Glutamine Synthase (GLUL) is primarily expressed in astrocytes in the brain. The main function of GLUL is to catalyze the condensation of glutamate and ammonia to form glutamine. GLUL plays an important role in the metabolic regulation of glutamate, detoxification of brain ammonia, as well as recycling of neurotransmitters. GLUL expression in endothelial cells may be involved in cell migration during pathological angiogenesis. Upregulation of astrocytic GLUL to uptake excess ammonia and glutamate may play a neuroprotective role during neuroinflammation.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human GLUL protein expressed in HEK293T cell
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P, ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg/mL for chromogenic staining and 0.5 - 5.0 µg/mL for fluorescent staining is suggested. For immunocytochemistry, a concentration range of 2.0 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
-
Application References
(PubMed link indicates BioLegend citation) -
- Shajahan-Haq AN, et al. 2014. Mol Cancer. 13:239. (WB)
- RRID
-
AB_2783452 (BioLegend Cat. No. 856201)
AB_2783452 (BioLegend Cat. No. 856202)
Antigen Details
- Structure
- GLUL is a 373 amino acid protein with an apparent molecular mass of ~ 42 kD.
- Distribution
-
Tissue Distribution: Predominantly expressed in brain, kidney, and liver.
Cellular Distribution: Extracellular, cytosol, nucleus, and mitochondrion. - Interaction
- Forms homooctamer and homotetramer.
- Cell Type
- Astrocytes
- Biology Area
- Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Postsynaptic proteins, Presynaptic proteins
- Antigen References
-
- Eelen G, et al. 2018. Nature. (7721):63-69
- Spodenkiewicz M, et al. 2016. Biology (Basel). 5(4)
- Fan S, et al. 2018. J Cell Biochem. 119(7):6008
- Gene ID
- 2752 View all products for this Gene ID 14645 View all products for this Gene ID 24957 View all products for this Gene ID
- UniProt
- View information about Glutamine synthetase on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Glutamine synthetase Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Glutamine synthetase | O91F4 | WB,IHC-P,ICC |
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Purified anti-Glutamine synthetase
Western blot of purified anti-Glutamine synthetase antibody ... IHC staining of purified anti-Glutamine synthetase antibody ... IHC staining of purified anti-Glutamine synthetase antibody ... IHC staining of purified anti-Glutamine synthetase antibody ... IHC staining of purified anti-Glutamine synthetase antibody ... ICC staining of purified anti-Glutamine synthetase antibody ...
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