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Purified anti-human CD110 Antibody

Pricing & Availability
Clone
S16017E (See other available formats)
Regulatory Status
RUO
Other Names
TPOR, c-MPL, MPLV
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
S16017E_PURE_CD110_Antibody_071318
Resting human platelets were stained with purified anti-human CD110 (clone S16017E, filled histogram) or with purified mouse IgG2a, κ isotype control (open histogram), followed by PE goat anti-mouse IgG.
  • S16017E_PURE_CD110_Antibody_071318
    Resting human platelets were stained with purified anti-human CD110 (clone S16017E, filled histogram) or with purified mouse IgG2a, κ isotype control (open histogram), followed by PE goat anti-mouse IgG.
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393701 25 µg 67€
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393702 100 µg 160€
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Description

CD110 is a type I transmembrane glycoprotein which functions as a receptor for thrombopoietin; binding causes the proliferation and differentiation of megakaroyocytes in addition to the production of platelets and protection of stem cells from apoptosis. CD110 is primarily expressed on hematopoietic stem cells, hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CD110 transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Xu L, et al. 2020. Nat Cell Biol. 1162:22. PubMed
RRID
AB_2750048 (BioLegend Cat. No. 393701)
AB_2750048 (BioLegend Cat. No. 393702)

Antigen Details

Structure
Type I transmembrane glycoprotein
Distribution

Hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.

Function
Megakaryocytopoiesis and platelet formation
Interaction
THPO, ATXN2L, JAK2
Ligand/Receptor
Thrombopoietin
Cell Type
Hematopoietic stem and progenitors, Megakaryocytes, Platelets
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Ninos JM, et al. 2006. J. Transl. Med. 16:4-9.
  2. Broudy VC, et al. 1996. Blood. 88:2026-32.
  3. Wang X, et al. 2016. Blood. 127:3398-409.
Gene ID
4352 View all products for this Gene ID
UniProt
View information about CD110 on UniProt.org
Go To Top Version: 1    Revision Date: 07.13.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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