- Clone
- HP-3G10 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- NKR-P1A
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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339919 | 100 µg | 128€ |
CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.
Product DetailsProduct Details
- Verified Reactivity
- Human, Cynomolgus, Rhesus
- Reported Reactivity
- African Green, Baboon
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human NK cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
CyTOF® - Verified - Recommended Usage
-
This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies.
- Application Notes
-
Additional reported applications (for the relevant formats) include: inhibition of cytokine production and Western blotting under nonreducing conditions.
- Additional Product Notes
-
Maxpar® is a registered trademark of Standard BioTools Inc.
-
Application References
(PubMed link indicates BioLegend citation) -
- Gumß M, et al. 2004. Blood 104:3664.
- Exley M, et al. 1998. J. Exp. Med. 188:867.
- Marquez C, et al. 1998. Blood 91:2760.
- Product Citations
-
- RRID
-
AB_2562836 (BioLegend Cat. No. 339919)
Antigen Details
- Structure
- Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily
- Distribution
-
NK cells, T subset, subset of CD3+ thymocytes
- Ligand/Receptor
- LLT-1 (Lectin-like transcript-1)
- Cell Type
- NK cells, T cells, Thymocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
-
1. Takahashi T, et al. 2006. J. Immunol. 176:211.
2. Cosmi L, et al. 2008. J. Exp. Med. 205:1903.
3. Aldemir H, et al. 2005. J. Immunol. 175:7791.
4. Rosen DB, et al. 2008. J. Immunol. 180:6508. - Gene ID
- 3820 View all products for this Gene ID
- UniProt
- View information about CD161 on UniProt.org
Related FAQs
- Can I obtain CyTOF data related to your Maxpar® Ready antibody clones?
-
We do not test our antibodies by mass cytometry or on a CyTOF machine in-house. The data displayed on our website is provided by Fluidigm®. Please contact Fluidigm® directly for additional data and further details.
- Can I use Maxpar® Ready format clones for flow cytometry staining?
-
We have not tested the Maxpar® Ready antibodies formulated in solution containing EDTA for flow cytometry staining. While it is likely that this will work in majority of the situations, it is best to use the non-EDTA formulated version of the same clone for flow cytometry testing. The presence of EDTA in some situations might negatively affect staining.
- I am having difficulty observing a signal after conjugating a metal tag to your Maxpar® antibody. Please help troubleshoot.
-
We only supply the antibody and not test that in house. Please contact Fluidigm® directly for troubleshooting advice: http://techsupport.fluidigm.com/
- Is there a difference between buffer formulations related to Maxpar® Ready and purified format antibodies?
-
The Maxpar® Ready format antibody clones are formulated in Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. The regular purified format clones are formulated in solution that does not contain any EDTA. Both formulations are however without any extra carrier proteins.
Other Formats
View All CD161 Reagents Request Custom ConjugationCustomers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Brilliant Violet 510™ anti-human CD161
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FITC anti-human CD161
Human peripheral blood lymphocytes stained with HP-3G10 FITC... -
Purified anti-human CD161
-
PE anti-human CD161
Human peripheral blood lymphocytes stained with CD4 FITC and... Human peripheral blood CD4+ lymphocytes stained with CCR6 Pe... -
PerCP/Cyanine5.5 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 APC... -
Alexa Fluor® 647 anti-human CD161
Human peripheral blood lymphocytes stained with HP-3G10 Alex... -
APC anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
Brilliant Violet 421™ anti-human CD161
Human peripheral blood lymphocytes stained with CD4 FITC and... -
Brilliant Violet 605™ anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
PE/Cyanine7 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
Alexa Fluor® 700 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
Purified anti-human CD161 (Maxpar® Ready)
Human PBMCs stained with 145Nd-anti-CD4 (RPA-T4) and 159Tb-a... -
Alexa Fluor® 488 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 APC... -
Pacific Blue™ anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 APC... -
APC/Cyanine7 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
Brilliant Violet 785™ anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 APC... -
Biotin anti-human CD161
Human peripheral blood lymphocytes were stained with biotiny... -
PerCP anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
PE/Dazzle™ 594 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FIT... -
APC/Fire™ 750 anti-human CD161
Human peripheral blood lymphocytes were stained with CD4 FI... -
TotalSeq™-A0149 anti-human CD161
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TotalSeq™-C0149 anti-human CD161
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TotalSeq™-B0149 anti-human CD161
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PE/Cyanine5 anti-human CD161 Antibody
Human peripheral blood lymphocytes were stained with FITC an... -
TotalSeq™-D0149 anti-human CD161
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Spark Red™ 718 anti-human CD161
Human peripheral blood lymphocytes were stained with anti-hu... -
Brilliant Violet 711™ anti-human CD161
Human peripheral blood lymphocytes were stained with anti-hu...
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