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Purified anti-human CD84 Antibody

Pricing & Availability
Clone
CD84.1.21 (See other available formats)
Regulatory Status
RUO
Other Names
Ly9b, SLAMF5, GR6
Isotype
Mouse IgG2a, κ
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Product Citations
publications
CD84dot1dot21_Pure_021808
Human peripheral blood lymphocytes stained with purified CD84.1.21, followed by anti-mouse IgG FITC
  • CD84dot1dot21_Pure_021808
    Human peripheral blood lymphocytes stained with purified CD84.1.21, followed by anti-mouse IgG FITC
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326002 100 µg 104€
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Description

CD84 is a 64-82 kD glycoprotein. It is a member of the SLAM (CD150) family, a CD2 subset of the Ig superfamily, also known as SLAMF5 or Ly9b. CD84 is expressed on B cells, monocytes, thymocytes, subset of (preferentially on CD45RO+) T cells, and platelets. CD84 functions as a homophilic adhesion molecule and enhances T cell activation and cytokine production. The antibody CD84.1.21 is able to enhance CD3 induced IFN-γ production and partially block CD84-Ig binding to lymphocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
300.19 cell line transfected with the CD84 full-length DNA
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported (for the relevant formats) applications include: immunoprecipitation2, and enhancing CD3 induced IFN-? production1 and partially block CD84-Ig binding to lymphocytes1.

Application References

(PubMed link indicates BioLegend citation)
  1. Martin M, et al. 2001. J. Immunol. 167:3668.
  2. Sayós J, et al. 2001. Blood 97:3867.
  3. Morra M, et al. 2001. EMBO 20:5840.
  4. Morra M, 2001. J. Biol. Chem. 276:36809.
  5. Romero X, et al. 2004. Tissue Antigens 64:132.
Product Citations
  1. Baskar R, et al. 2022. Cell Rep Methods. 2:. PubMed
RRID
AB_830813 (BioLegend Cat. No. 326002)

Antigen Details

Structure
64-82 kD glycoprotein, CD2 subset of Ig superfamily, SLAM family
Distribution

B cells, monocytes, thymocytes, platelets, subset of (preferentially on CD45RO+) T cells

Function
Homophilic adhesion, T cell activation
Ligand/Receptor
CD84
Cell Type
B cells, Monocytes, Platelets, T cells, Thymocytes
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. de la Fuente MA, et al. 1997. Blood 90 (6):2398.
2. Tangye SG, et al. 2002. Eur. J. Immunol. 32(6):1640.
3. Tangye SG, et al. 2003. J. Immunol. 171:2485.
4. Martin M, et al. 2001. J. Immunol. 167:3668.

Gene ID
8832 View all products for this Gene ID
UniProt
View information about CD84 on UniProt.org
Go To Top Version: 2    Revision Date: 08.25.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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