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Purified anti-human CD98 Recombinant Antibody

Pricing & Availability
Clone
2B6/CD98.Rec (See other available formats)
Regulatory Status
RUO
Other Names
4F2, FRP-1, RL-388
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
a. 2B6-CD98Rec_PURE_CD98_FC-1_100924
Human peripheral blood cells were stained with purified anti-human CD98 recombinant (clone 2B6/CD98.Rec) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
  • a. 2B6-CD98Rec_PURE_CD98_FC-1_100924
    Human peripheral blood cells were stained with purified anti-human CD98 recombinant (clone 2B6/CD98.Rec) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
  • b. 2B6-CD98Rec_PURE_CD98_FC-2_100924
    Human peripheral blood lymphocytes were stained with purified anti-human CD98 recombinant (clone 2B6/CD98.Rec) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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335510 100 µg 212€
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Description

CD98, also known as 4F2 and FRP-1, is a 125 kD disulfide-linked heterodimer protein. It is broadly expressed on activated and transformed cells (hematopoietic and non-hematopoietic), and at low levels on quiescent cells. CD98 has been characterized as a potential amino acid transporter (neutral and dibasic amino acids) that is involved in lymphocyte activation and integrin signaling. CD98 is composed of a light chain (45 kD) and a heavy chain (80 kD). Studies with knock-out mice indicate that the CD98 heavy chain is involved in integrin-dependent cell spreading and protection against anchorage deprivation-induced apoptosis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Disulfide-linked heterodimer, 80 kD and 45 kD reduced, 125 kD unreduced
Distribution

Broadly expressed on activated and transformed cells, not hematopoietic cell-specific. Lower levels on resting cells.

Function
Potential amino acid transporter (neutral and dibasic amino acids) also involved in the activation of lymphocytes and integrin signaling. May be a target antigen for NK cells.
Interaction
Actin, β1 integrins (α2β1, α3β1, α5β1, α6β1; minimally with α4β1)
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Leukocyte Typing VI. Kishimoto T, et al. (Eds.) Garland Publishing Inc. (1997)
  2. Bron C, et al. 1986. J. Immunol. 137:397.
  3. Lumadue JA, et al. 1987. Proc. Natl. Acad. Sci. 84:9204.
  4. Mastroberardino L, et al. 1998. Nature 395:288.
Gene ID
6520 View all products for this Gene ID
UniProt
View information about CD98 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 10.09.2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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