- Clone
- A20095I (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD87, MO3, Plasminogen activator urokinase receptor, uPAR, URKR
- Isotype
- Mouse IgM, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
632152 | 100 µg | 336€ |
PLAUR (plasminogen activator urokinase receptor), also known as urokinase plasminogen activator-receptor (uPAR), is part of the plasminogen activation system, which is involved in tissue reorganization, cell migration, cell cycle regulation, and cell adhesion. PLAUR was originally identified as a saturable binding site for urokinase on the cell surface, and thus, restricting plasminogen activation to the immediate vicinity of the cell membrane. Due to lack of transmembrane or cytoplasmic domains, PLAUR may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its C-terminus. A soluble form of PLAUR has been identified. The membrane-bound PLAUR is expressed on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. This molecule plays a role in cell adhesion and chemotaxis through binding to β1, β2, and β3 integrins. Recently, it was found that soluble PLAUR is increased in plasma of patients with active lupus nephritis, suggesting an association with pathological features of the disease. In addition, soluble PLAUR has been linked as a causative factor and also a biomarker of several diseases including tumor metastasis, focal and segmental glomerulosclerosis, hepatocellular carcinoma, and coronary artery disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Recombinant PLAUR (uPAR) Protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
Direct ELISA - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.
- Additional Product Notes
-
This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A20095I) could function as a capture antibody when paired with biotin anti-human PLAUR (uPAR) (Cat. No. 631453) (clone A20095T) as the detection antibody and using Recombinant Human PLAUR (uPAR) (carrier-free) protein (Cat. Nos. 559702, 559704, and 559706) as the assay standard.
- RRID
-
AB_3106038 (BioLegend Cat. No. 632152)
Antigen Details
- Structure
- Monomer
- Distribution
-
Granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes, and activated T cells
- Function
- Convert plasminogen to plasmin, cell adhesion, and chemotaxis
- Ligand/Receptor
- uPA; LRP1 (CD91)
- Cell Type
- Embryonic Stem Cells
- Biology Area
- Angiogenesis, Cell Biology, Stem Cells
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
- Llinas P, et al. 2005. EMBO J. 24:1655-63.
- Beaufort N, et al. 2004. J Immunol. 172:540-9.
- Tarui T, et al. 2001. J Biol Chem. 276:3983-90.
- Qin DD, et al. 2014. Lupus. 24:546-57.
- Thuno M, et al. 2009. Dis Markers. 27:157-72.
- Alfano D, et al. 2009. Front Biosci. 14:3782-94.
- Spinale JM, et al. 2014. Kidney Int. 87:564-74.
- Chounta A, et al. 2014. Liver Int. 35:601-7.
- Harskamp RE and Roe MT. 2014. J Am Heart Assoc. 3:e001431.
- Gene ID
- 5329 View all products for this Gene ID
- UniProt
- View information about PLAUR on UniProt.org
Related FAQs
Other Formats
View All PLAUR Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human PLAUR (uPAR) | A20095I | Direct ELISA |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human PLAUR (uPAR)
Direct ELISA showing purified anti-human PLAUR (uPAR) (clone...
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