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- Clone
- S20010A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Tetraspanin-8
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human colon cancer cell line, HT-29, was stained with purified anti-human TSPAN8 (clone S20010A) (filled histogram) or mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG PE. -
Human paraffin embedded colon tissue was subjected to heat-mediated antigen retrieval with sodium citrate and stained with 5 µg/mL purified anti-human TSPAN8 (clone S20010A) (red) followed by anti-mouse IgG Alexa Fluor® 555. Nuclei were counterstained with DAPI (blue). The image was captured by a 10X objective.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 378902 | 100 µg | 207€ | ||||
Tetraspanin 8 (TSPAN8) is a member of the transmembrane IV superfamily. It is a cell surface protein with four hydrophobic domains. Tetraspanins are constitutive components of exosomes and are involved in adhesion, motility, matrix modulation and cell fusion. TSPAN8 mediates signal transduction events that regulate cell development, activation, growth, and motility. It is expressed in gastric, colon, rectal, and pancreatic carcinomas.
Product Details
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- huTSPAN8 transfectant
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IHC-P - Verified - Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2910444 (BioLegend Cat. No. 378902)
Antigen Details
- Structure
- Multi-pass membrane protein
- Distribution
-
Cell membrane, lysosomes
- Function
- Tyrosine-based internalization, recruitment into endosomes
- Interaction
- LIPR1, MEP1B, STX1-2, TIM23, S38A7
- Biology Area
- Immunology
- Antigen References
-
- Szala S, et al. 1990. Proc Natl Acad Sci USA. 87:6833-7.
- Rana S, et al. 2011. Int J Biochem Cell Biol. 43:106-19.
- Nazarenko I, et al. 2010. Cancer Res. 70:1668-78.
- Berthier-Vergnes O, et al. 2011. Br J Cancer. 104:155-68.
- Gene ID
- 7103 View all products for this Gene ID
- UniProt
- View information about TSPAN8 on UniProt.org
Related FAQs
Other Formats
View All TSPAN8 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human TSPAN8 | S20010A | FC,IHC-P |
| PE anti-human TSPAN8 | S20010A | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human TSPAN8
Human colon cancer cell line, HT-29, was stained with purifi... 
Human paraffin embedded colon tissue was subjected to heat-m... -
PE anti-human TSPAN8
Human colon cancer cell line, HT-29, was stained with anti-h...
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