- Clone
- A18167C (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Neuraminidase 1 (NEU1), sialidase 1 (SIAL1), sialidase-1 Acetylneuraminyl hydrolase (NANH), G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
623851 | 25 µg | 156€ | ||||
623852 | 100 µg | 396€ |
Neu1, a member of the sialidase enzyme family, plays a crucial role in cellular processes by removing sialic acid (N-acetylneuraminic acid) residues from glycoproteins and glycolipids on the cell surface. This process, known as desialylation, impacts various cellular functions, including cell-cell interactions, signal transduction, and immune responses. Additionally, desialylation recycles sialic acid, contributing to the maintenance of cellular sialic acid levels critical for normal physiological processes. Alterations in Neu1 activity leads to sialidosis, a lysosomal storage disease resulting in an accumulation of sugar-protein complexes.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- C-terminal fragment of recombinant human Neu1
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody (clone A18167C) is not suitable for Western blot (WB) or immunocytochemistry (ICC).
For immunohistochemistry (IHC), we recommend antigen retrieval with Tris-EDTA (10 mM Tris, 1 mM EDTA, 0.05% Tween-20, pH 9.0). Antigen retrieval with Sodium Citrate is not recommended. - RRID
-
AB_3097496 (BioLegend Cat. No. 623851)
AB_3097496 (BioLegend Cat. No. 623852)
Antigen Details
- Structure
- Neu1 is a 415 amino acid protein with a predicted molecular weight of 45.5 kD.
- Distribution
-
Cytoplasmic, lysosomal
- Function
- Sialidase, with a preference for alpha 2-3 and alpha 2-6 sialyl linkage
- Molecular Family
- Cytokines/Chemokines, Enzymes and Regulators
- Antigen References
-
- Khan A & Sergi CM. 2022. Front Pharmacol. 13:902259.
- Seyrantepe V, et al. 2003. Hum Mutat. 22:343-52
- Toussaint K, et al. 2022. Cancers. 14:4868.
- Gene ID
- 4758 View all products for this Gene ID
- UniProt
- View information about Neu1 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Neu1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Neu1 | A18167C | IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-Neu1
IHC staining of Purified anti-Neu1 (clone A18167C) on formal...
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