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APC anti-human Folate Receptor β (FR-β) Antibody

Pricing & Availability
Clone
94b/FOLR2 (See other available formats)
Regulatory Status
RUO
Other Names
FR-BETA
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
94bFOLR2_APC_FRB_Antibody_041018
Human peripheral blood monocytes were stained with CD14 FITC and anti-human FR-β (94b/FOLR2) APC (left) or APC Mouse IgG1, κ isotype control (right).
  • 94bFOLR2_APC_FRB_Antibody_041018
    Human peripheral blood monocytes were stained with CD14 FITC and anti-human FR-β (94b/FOLR2) APC (left) or APC Mouse IgG1, κ isotype control (right).
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391705 25 tests 114€
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391706 100 tests 290€
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Description

Folate receptors beta (FR-β) is a member of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. FR-β is a GPI-anchored protein with high affinity for folic acid. It is postulated that this receptor function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human Folate beta transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Nagayoshi R, et al. 2005. Arthritis Rheum. 9:2666
Product Citations
  1. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
  2. Appios A, et al. 2021. Bio Protoc. 11:e4044. PubMed
  3. Mulder K, et al. 2021. Immunity. 54(8):1883-1900.e5. PubMed
RRID
AB_2721302 (BioLegend Cat. No. 391705)
AB_2721302 (BioLegend Cat. No. 391706)

Antigen Details

Structure
30 kD, seven disulfide bonds
Distribution

Placenta, monocytes, tissue resident macrophages

Function
Transport of folate into cells
Ligand/Receptor
Folic Acid
Cell Type
Macrophages, Monocytes
Biology Area
Immunology
Antigen References
  1. Elwood PC. 1989. J Biol Chem. 264:14893
  2. Shen F, et al. 1994. Biochemistry. 33:1209
  3. Yi YS. 2016. Immune Netw. 16:337
Gene ID
2350 View all products for this Gene ID
UniProt
View information about Folate Receptor beta on UniProt.org
Go To Top Version: 0    Revision Date: 10.31.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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