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Biotin anti-human CD120a Antibody

Pricing & Availability
Clone
W15099A (See other available formats)
Regulatory Status
RUO
Other Names
TNFR-I, TNFRSF1A, P55, P60
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
W15099A_Biotin_CD120a_Antibody_022017
Human peripheral blood monocytes were stained with biotinylated anti-human CD120a (clone W15099A) (filled histogram) or biotinylated mouse IgG2a, κ isotype control (open histogram), followed by SAV-PE.
  • W15099A_Biotin_CD120a_Antibody_022017
    Human peripheral blood monocytes were stained with biotinylated anti-human CD120a (clone W15099A) (filled histogram) or biotinylated mouse IgG2a, κ isotype control (open histogram), followed by SAV-PE.
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369908 100 µg 212€
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Description

CD120a, also known as tumor necrosis factor receptor type 1 (TNF-R1) is 55 kD member of tumor necrosis receptor superfamily (TNFRSF) which which upon binding tumor necrosis factor alpha (TNFα), homotrimerizes  to interact death domain of TRADD. CD120a, in association with TRADD, leads to activation of NF-κB signaling, in addition to apoptotic and inflammatory responses.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full length human CD120a transfectant cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Herati RS, et al. 2021. Cell Reports Medicine. 2(5):100262. PubMed
  2. Volpin V, et al. 2020. Cancer Immunol Res. 8:1163. PubMed
RRID
AB_2650932 (BioLegend Cat. No. 369908)

Antigen Details

Structure
55 kD, single pass type 1 membrane protein, TNFR superfamily.
Distribution
Granulocytes, monocytes, and lymphocytes.
Function
Homotrimerizes upon binding TNF, activates apoptotic and NFkB signaling.
Ligand/Receptor
TNFα, LTα (TNFβ)
Cell Type
Granulocytes, Monocytes, Lymphocytes, Neutrophils, Eosinophils
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Loetscher H, et al. 1990. Proc. Natl. Acad. Sci. USA 87:3127.
2. Crowe PD, et al. 1994. J. Immunol. 264:707.
3. Aggarwal BB, et al. 1985. J. Biol. Chem. 260:2345.
4. Chan FK, et al. 2000. Science. 288:2351.
5. Sugano M, et al. 2002. Atherosclerosis 162:77.
6. Cottin V, et al. 2002. J. Immunol. 168:4095.
7. Barnhart BC, Peter ME. 2003. Cell. 114:148. 

Gene ID
7132 View all products for this Gene ID
UniProt
View information about CD120a on UniProt.org

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 0    Revision Date: 03.09.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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