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- Clone
- S19014A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CAMPATH-1 antigen
- Isotype
- Rat IgM, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 (clone 17A2) PE and anti-mouse CD52 (clone S19014A) FITC (left) or rat IgM, κ FITC isotype control (right).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 166005 | 25 µg | 113€ | ||||
| 166006 | 100 µg | 306€ | ||||
CD52, also known as Cambridge pathology antigen 1 (CAMPATH-1), is a 25-29 kD glycoprotein containing a large N-linked carbohydrate moiety. The actual molecule of CD52 is only 8-9 kD. It is expressed in the male reproductive tract and on virtually all lymphocytes (T and B cells), as well as macrophages/monocytes, eosinophils, and red cells. CD52 is thought to play a role in carrying and orienting carbohydrates. CD52 is a potent target for complement-mediated lysis and antibody-mediated cellular cytotoxicity and has been used as a depletion target for chronic lymphocytic leukemia (CLL)/lymphoma and immunosuppression.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Antigen Details
- Structure
- CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI).
- Distribution
-
Expressed on lymphohematopoietic tissues, including thymus, spleen, and bone marrow, but not in liver, kidney, and brain
- Function
- Promote cell-mediated killing (antibody-dependent cellular cytotoxicity)
- Cell Type
- Dendritic cells, Lymphocytes, Mesenchymal Stem Cells, Monocytes, Thymocytes
- Biology Area
- Cell Adhesion
- Molecular Family
- Adhesion Molecules
- Antigen References
-
- Gudrun R, et al. 2002. Blood. 101:1422.
- Gene ID
- 23833 View all products for this Gene ID
- UniProt
- View information about CD52 on UniProt.org
Related FAQs
Other Formats
View All CD52 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| FITC anti-mouse CD52 | S19014A | FC |
| Alexa Fluor® 647 anti-mouse CD52 | S19014A | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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FITC anti-mouse CD52
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 (... -
Alexa Fluor® 647 anti-mouse CD52
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 (...
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