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PE anti-human CD155 (PVR) Antibody

Pricing & Availability
Clone
SKII.4 (See other available formats)
Regulatory Status
RUO
Other Names
Poliovirus receptor (PVR), nectin-like 5
Isotype
Mouse IgG1, κ
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Product Citations
publications
SKII4_PE_111208.jpg
Human histiocytic lymphoma cells U-937 stained with SKII.4 PE
  • SKII4_PE_111208.jpg
    Human histiocytic lymphoma cells U-937 stained with SKII.4 PE
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Cat # Size Price Quantity Check Availability Save
337609 25 tests 117€
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337610 100 tests 235€
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Description

CD155, known as poliovirus receptor (PVR) or nectin-like 5, is a 70 kD type I transmembrane glycoprotein. It is a nectin-like molecule belonging to Ig superfamily. CD155 is primarily found on endothelial cells, monocytes, epithelia and central nervous system. CD155 is an adhesion molecule involved in cell-cell and cell-matrix adhesion through interaction with CD226, CD96 (Tactile), nectin-1, -2, and -3 (CD111, CD112, CD113), and vitronectin. It also serves as a receptor for poliovirus and cytomegalovirus.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
SK-N-S1 human neuroblastoma cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications include: block binding of PVR ligands CD226 and CD96 to PVR, immunoprecipitation, and western blot.

Application References

(PubMed link indicates BioLegend citation)
  1. Fuchs A, et al. 2004. J. Immunol. 172:3994
Product Citations
  1. Aarsund M, et al. 2022. Cancer Immunol Immunother. 71:2227. PubMed
  2. Asashima H, et al. 2022. J Clin Invest. 132: . PubMed
  3. Sano Y, et al. 2023. Anticancer Res. 43:547. PubMed
  4. Taylor J, et al. 2023. Front Immunol. 14:1119350. PubMed
  5. Jacobs ME, et al. 2021. Immunother Adv. 1:ltaa004. PubMed
  6. Eri Yamada et al. 2018. Cell host & microbe. 23(1):110-120 . PubMed
  7. Trotta AM, et al. 2018. J Exp Clin Cancer Res. 37:297. PubMed
  8. Poznanski SM, et al. 2018. Cancer Immunol Res. 1.065277778. PubMed
  9. Grandclaudon M, et al. 2019. Cell. 179:432. PubMed
  10. Zhang X, et al. 2021. Front Immunol. 12:602492. PubMed
  11. Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
  12. Kim N, et al. 2020. Cancers (Basel). 12:. PubMed
  13. Carré T, et al. 2020. Oncol Rep. . PubMed
  14. Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
RRID
AB_2174019 (BioLegend Cat. No. 337609)
AB_2174019 (BioLegend Cat. No. 337610)

Antigen Details

Structure
Type I glycoprotein, Ig superfamily
Distribution

Monocytes, endothelial cells, epithelia, central nervous system

Function
Cell-cell and cell-matrix adhesion
Ligand/Receptor
CD226, CD96, nectin-1, -2, and -3, vitronectin, CD155, poliovirus
Cell Type
Endothelial cells, Epithelial cells, Monocytes, Tregs
Biology Area
Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Bottino PD, et al. 2005. Mol. Immunol. 42:463
3. Tahara-Hanaoka S, et al. 2004. Intl. Immunol. 16:533

Gene ID
5817 View all products for this Gene ID
UniProt
View information about CD155 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 05.29.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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