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PE anti-human CD279

Pricing & Availability

Analyte Specific Reagent. Analytical and performance characteristics are not established.

Clone
NAT105
Other Names
PD1
Isotype
Mouse IgG1, κ
NAT105_PE_CD279_ASR_072423
Typical results from PHA-stimulated human peripheral blood lymphocytes stained either with NAT105 PE used at 5 μL/test (filled histogram) or with an isotype control (open histogram).
  • NAT105_PE_CD279_ASR_072423
    Typical results from PHA-stimulated human peripheral blood lymphocytes stained either with NAT105 PE used at 5 μL/test (filled histogram) or with an isotype control (open histogram).
Compare all formats See PE spectral data
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981602 500 µL 258€
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Description

CD279, also known as Programmed cell death 1 (PD-1), is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune diseases. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. The interaction with CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Formulation
Phosphate-buffered solution, pH7.2, containing 0.09% sodium azide, 0.2% (w/v) BSA (origin USA), and a stabilizer.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
100 µg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

Suggested for Flow Cytometry
Disclaimer

WARNINGS AND PRECAUTIONS

  1. Use appropriate personal protective equipment and safety practices per universal precautions when working with this reagent. Refer to the reagent safety data sheet.
  2. This antibody contains sodium azide. Follow federal, state and local regulations to dispose of this reagent. Sodium azide build-up in metal wastepipes may lead to explosive conditions; if disposing of reagent down wastepipes, flush with water after disposal.
  3. All specimens, samples and any material coming in contact with them should be considered potentially infectious and should be disposed of with proper precautions and in accordance with federal, state and local regulations.
  4. Do not use this reagent beyond the expiration date stated on the label.
  5. Do not use this reagent if it appears cloudy or if there is any change in the appearance of the reagent as these may be an indication of possible deterioration.
  6. Avoid prolonged exposure of the reagent or stained cells to light.

Antigen Details

Antigen References
  1. Francisco LM, et al. 2010. Immunological Rev. 236:219.
Go To Top Version: 1    Revision Date: 08.18.2023

Analyte Specific Reagent. Analytical and performance characteristics are not established.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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