- Clone
- 509f6 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD307, IRTA2, FcRH5, IFGP5, BXMAS1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
340304 | 100 tests | 288€ |
FcRL5, also known as CD307e, CD307, IRTA2, FcRH5, and BXMAS1, is a 106 kD type I transmembrane glycoprotein composed of six-eight extracellular Ig like C2 domains and two cytoplasmic ITIM motifs. The FcRL5 gene is located on chromosome 1q21 and is normally expressed by tonsillar plasma cells and germinal center B cells. It has been suggested that FcRL5 contributes to B cell maturation and B cell receptor modulation. The identification of FcRL5 on a number of transformed cell types including hairy cell leukemia, mantle cell lymphoma, chronic lymphocytic lymphoma, and Burkitt’s lymphoma has prompted interest in it as a potential biomarker or target for immunotherapy. FcRL5 binds all aggregated IgG isotypes.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- P815 cells transfected with FcRL5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: immunoprecipitation and blocking1. mAb 509f6 is able to block the binding of FcRL5 to all aggregated IgG isotypes.1
-
Application References
(PubMed link indicates BioLegend citation) -
- Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)
- Product Citations
-
- RRID
-
AB_2104588 (BioLegend Cat. No. 340304)
Antigen Details
- Structure
- 106 kD, Fc receptor like, type 1 transmembrane protein, 6-8 Ig like C2 domains, 2 cytoplasmic ITIM motifs.
- Distribution
-
Germinal center B cells, tonsillar plasma cells.
- Ligand/Receptor
- Aggregated IgG
- Cell Type
- B cells, Plasma cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Davis R, et al. 2007. Annu. Rev. Immunol. 207:528.
2. Mohan J, et al. 2006. Blood 107:4433.
3. Ise T, et al. 2007. Leukemia. 21:169. - Gene ID
- 83416 View all products for this Gene ID
- UniProt
- View information about CD307e on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD307e Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD307e (FcRL5) | 509f6 | FC,IP |
PE anti-human CD307e (FcRL5) | 509f6 | FC |
APC anti-human CD307e (FcRL5) | 509f6 | FC |
TotalSeq™-C0829 anti-human CD307e (FcRL5) | 509f6 | PG |
TotalSeq™-B0829 anti-human CD307e (FcRL5) Antibody | 509f6 | PG |
TotalSeq™-D0829 anti-human CD307e (FcRL5) | 509f6 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD307e (FcRL5)
-
PE anti-human CD307e (FcRL5)
FcRL5 transfected P815 cells stained with 509f6 PE -
APC anti-human CD307e (FcRL5)
Human FcRL5 transfected P815 cell line was stained with CD30... -
TotalSeq™-C0829 anti-human CD307e (FcRL5)
-
TotalSeq™-B0829 anti-human CD307e (FcRL5) Antibody
-
TotalSeq™-D0829 anti-human CD307e (FcRL5)
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