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PE anti-mouse CD136 (Mst1r) Antibody

Pricing & Availability
Clone
S20018D (See other available formats)
Regulatory Status
RUO
Other Names
MSP receptor, CD136, RON, STK
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
S20018D_PE_Mst1r_Antibody_032523
C57BL/6 resident mouse peritoneal macrophages were stained with anti-mouse CD136 (Mst1r) (clone S20018D) (left) PE or rat IgG1, κ PE isotype control (right). Cells were costained for anti-mouse F4/80 APC.
  • S20018D_PE_Mst1r_Antibody_032523
    C57BL/6 resident mouse peritoneal macrophages were stained with anti-mouse CD136 (Mst1r) (clone S20018D) (left) PE or rat IgG1, κ PE isotype control (right). Cells were costained for anti-mouse F4/80 APC.
See PE spectral data
Cat # Size Price Quantity Check Availability Save
112403 25 µg 133€
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112404 100 µg 333€
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Description

Macrophage-stimulating 1 receptor (MST1R/RON) is a receptor protein kinase that transduce signals from the extracellular matrix into the cytoplasm by binding to the macrophage-stimulating protein (MSP). MST1R regulates various physiological processes including cell adhesion, motility, growth, and survival. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, it interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. RON plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than the MST1 ligand.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
MST1R transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2941389 (BioLegend Cat. No. 112403)
AB_2941389 (BioLegend Cat. No. 112404)

Antigen Details

Structure
The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35 kD (alpha) and 150 kD (beta) subunits
Distribution

Myeloid progenitor, monocytes, granulocytes, dendritic cells, mast cells

Function
Cell adhesion, motility, differentiation and host defense
Interaction
Macrophages, dendritic cells, granulocytes, hematopoietic stem and progenitors
Ligand/Receptor
MST1 ligand
Molecular Family
CD Molecules
Antigen References
  1. Nikolaidis NM, et al. 2011. Innate Immun. 17:499–507.
  2. Bezerra JA, et al. 1993. Hepatology. 18:394–9.
Gene ID
19882 View all products for this Gene ID
UniProt
View information about CD136 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 03.24.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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