- Clone
- MHN2-25 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Neurogenic locus notch homolog protein 2, hN2, fN2
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
348301 | 25 µg | 100€ |
The Notch receptors are a type I transmembrane protein family that share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. They are highly conserved from invertebrates to mammals. Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors (Notch1-4). Notch1 and Notch 2 are reported to be functionally redundant. Notch 2 is expressed by Pre-B cells, double negative and CD8 single positive thymocytes, brain, lung cells. Notch 2 functions as a receptor for Jagged and Delta ligands, and may play a role in vascular, renal and hepatic development.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- African Green
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Notch 2-human IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
-
Application References
(PubMed link indicates BioLegend citation) -
- Haraguchi K, et al. 2009. J. Immunol. 182:6168.
- RRID
-
AB_10551623 (BioLegend Cat. No. 348301)
Antigen Details
- Distribution
-
Double negative and CD8 single positive thymocytes, pre-B cells, brain, lung
- Ligand/Receptor
- Jag 1, Jag 2; Delta 1, Delta 4
- Cell Type
- B cells, Neural Stem Cells, Thymocytes
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Antigen References
-
1. Haraguchi K, et al. 2009. J. Immunol. 182:6168.
2. O’Neill CF, et al.2007. Am. J. Path. 171:1023.
3. Bertrand FE, et al. 2000. Leukemia 14:2095. - Gene ID
- 4853 View all products for this Gene ID
- UniProt
- View information about Notch 2 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Notch 2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
APC anti-human Notch 2 | MHN2-25 | FC |
Purified anti-human Notch 2 | MHN2-25 | FC |
PE anti-human Notch 2 | MHN2-25 | FC |
TotalSeq™-A1133 anti-human Notch 2 Antibody | MHN2-25 | PG |
TotalSeq™-C1133 anti-human Notch 2 | MHN2-25 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
APC anti-human Notch 2
Human Notch-2 transfected CHO cells stained with Notch-2 (cl... -
Purified anti-human Notch 2
Human Notch2 transfected CHO cells stained with purified MHN... Human pre-B cell line NALM16 stained with MHN2-25 PE -
PE anti-human Notch 2
Human Notch 2 transfected CHO cells stained with MHN2-25 PE ... Human pre-B cell line NALM16 stained with MHN2-25 PE -
TotalSeq™-A1133 anti-human Notch 2 Antibody
-
TotalSeq™-C1133 anti-human Notch 2
Follow Us