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- Clone
- SA065C3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- M83, TMEM6, TMEM8, Transmembrane protein 8A
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with purified TMEM8A (clone SA065C3) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram), followed by anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 370802 | 100 µg | 212€ | ||||
TMEM8A is an 84 kD, type I protein with five transmembrane-spanning regions. TMEM8A is expressed on the surface of resting T cells and is down-regulated after cell activation. In addition, there are reports of TMEM8A co-localizing with LAMP2 in the lysosome. While the exact function of TMEM8A is unknown, it has been proposed to be an adhesion molecule that may be involved in the maintenance of the resting T cell state.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TMEM8A transfected cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
ICC, WB - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone SA065C3 is also known as 5C31. Additional reported applications (for the relevant formats) include: immunofluorescence1 and Western blotting1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Lee GH, et al. 2016. J Cell Biol. 10.1083/jcb.201605121. (IF, WB) PubMed
- RRID
-
AB_2571923 (BioLegend Cat. No. 370802)
Antigen Details
- Structure
- 84 kD type I protein with five transmembrane-spanning regions.
- Distribution
-
Resting T cells, down-regulated after cell activation.
- Cell Type
- T cells
- Biology Area
- Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology
- Antigen References
-
1. Motohashi T, et al. 2000. Biochem. Biophys. Res. Commun. 276:244.
2. Schröder B, et al. 2007. Traffic 8:1676.
3. Palmieri M, et al. 2011. Hum. Mol. Genet. 20:3852. - Gene ID
- 58986 View all products for this Gene ID
- UniProt
- View information about TMEM8A on UniProt.org
Related FAQs
Other Formats
View All TMEM8A Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human TMEM8A | SA065C3 | FC,ICC,WB |
| PE anti-human TMEM8A | SA065C3 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human TMEM8A
Human peripheral blood lymphocytes were stained with purifie... -
PE anti-human TMEM8A
Human peripheral blood lymphocytes were stained with CD3-APC... 
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