Purified anti-mouse CD178 (FasL) Antibody

Pricing & Availability
Clone
A19116F (See other available formats)
Regulatory Status
RUO
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
A19116F_-Purified_-CD178_Antibody_031723
Mouse Fas Ligand transfected cells were stained with purified anti-mouse CD178 (FasL) (clone A19116F) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram) followed by anti-mouse IgG2a Alexa Fluor® 647.
  • A19116F_-Purified_-CD178_Antibody_031723
    Mouse Fas Ligand transfected cells were stained with purified anti-mouse CD178 (FasL) (clone A19116F) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram) followed by anti-mouse IgG2a Alexa Fluor® 647.
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134202 100 µg 159€
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Description

CD178 is a 40 kD member of the TNF superfamily also known as Fas ligand or FasL. Cell surface CD178 is expressed on activated T cells and in testis and eye. CD178 is upregulated in activated T cells upon TCR re-engagement and has been shown to induce T cell death. CD178 expression in the eye and testis has been shown to participate in immune privilege at these sites. CD178 can be cleaved from the surface by metalloproteases, and "soluble" CD178 may block the activities of membrane-bound CD178. CD178 binds to CD95 (Fas) to induce apoptotic cell death implicated in the maintenance of peripheral tolerance. CD178/CD95 interactions have also been implicated in the proliferation of CD8+ cells and neutrophil extravasation, chemotaxis, and survival. 

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant mouse FasL
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone A19116F does not affect the binding of clone MFL3 on target cells.

RRID
AB_2936669 (BioLegend Cat. No. 134202)

Antigen Details

Structure
TNF superfamily, 40 kD
Distribution

Activated T cells, spleen, testis, eye

Function
Induces apoptosis
Ligand/Receptor
Fas (CD95)
Cell Type
T cells, Tregs
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Cell Biology, Immunology, Neuroscience
Molecular Family
CD Molecules
Antigen References
  1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
  2. Nagata S. 1999. Annu Rev Genet. 33:29-55.
  3. Takahashi T, et al. 1994. Cell. 76:969-76.
  4. Hill LL, et al. 1999. Science. 285:898-900.
Gene ID
14103 View all products for this Gene ID
UniProt
View information about CD178 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03.17.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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