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Purified anti-mouse CXCL9 (MIG) Antibody

Pricing & Availability
Clone
MIG-2F5.5 (See other available formats)
Regulatory Status
RUO
Other Names
MIG-1, MIG
Isotype
Armenian Hamster IgG
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Product Citations
publications
A_MIG-2F5_A647_100609.jpg
IFN-g stimulated peritoneal macrophages intracellular stained with purified MIG-2F5 conjugated to Alexa Fluor® 647 and CD11b (M1/70) FITC
  • A_MIG-2F5_A647_100609.jpg
    IFN-g stimulated peritoneal macrophages intracellular stained with purified MIG-2F5 conjugated to Alexa Fluor® 647 and CD11b (M1/70) FITC
  • B_MIG-2F5_A647_100609.jpg
    IFN-g stimulated peritoneal macrophages intracellularly stained with Armenian Hamster IgG Alexa Fluor® 647 and CD11b (M1/70) FITC
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Cat # Size Price Quantity Check Availability Save
515601 25 µg 81€
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515602 100 µg 175€
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Description

MIG, also known as mig-1, CXCL9, is a member of the alpha subfamily of inflammatory chemokine. It is inducible in macrophages, hepatocytes, and endothelial cells by IFN-γ, but not by TNF-α or bacterial lipopolysacchrides (LPS). Mig functions as a chemotactic factor for resting memory and activated T cells, both CD4+ and CD8+, and natural killer cells. Furthermore, it was reported that Mig induced both calcium signals and chemotaxis in activated B cells and that B cell activation induced expression of mouse CXCR3. MIG and CXCR3 may be important not only to recruit T cells to peripheral inflammatory sites, but also in some cases to maximize interactions among activated T cells, B cells, and dendritic cells within lymphoid organs to provide optimal humoral responses to pathogens.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Mugarza E, et al. 2022. Sci Adv. 8:eabm8780. PubMed
  2. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  3. Xiong Y, et al. 2016. J Immunol. 196: 2526 - 2540. PubMed
  4. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
RRID
AB_2086732 (BioLegend Cat. No. 515601)
AB_2086732 (BioLegend Cat. No. 515602)

Antigen Details

Structure
A member of the alpha subfamily of inflammatory chemokine.
Distribution

Inducible in macrophages, hepatocytes, and endothelial cells by IFN-γ.

Function
Recruit T cells to peripheral inflammatory sites, maximize interactions among activated T cells, B cells, and dendritic cells within lymphoid organs.
Ligand/Receptor
CXCR3
Cell Type
Macrophages
Biology Area
Immunology
Molecular Family
Cytokines/Chemokines
Antigen References

1. Thapa M et al. 2008. J. Immunol. 180(2):1098
2. Whiting D et al. 2004. J. Immunol. 172 (12):7417
3. Helbig KJ. et al. 2009. J Virol. 83(2):836

Gene ID
4283 View all products for this Gene ID
UniProt
View information about CXCL9 on UniProt.org
Go To Top Version: 2    Revision Date: 08.29.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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