- Clone
- RMT2-1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell immunoglobulin and mucin domain containing protein-2
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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119602 | 500 µg | 315€ |
Tim-2 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-2. It is expressed on activated T cells and preferentially on differentiated Th2 cells. Sema4A is the ligand of Tim-2. A blockade of Tim-2/Tim-2 ligand interaction results in T cell hyperproliferation and Th2 cytokine production. Tim-2 plays a critical role in the development of atopic disease and other Th2-biased immune responses.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance in each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
- RRID
-
AB_345372 (BioLegend Cat. No. 119602)
Antigen Details
- Structure
- Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD
- Distribution
- Developmentally regulated; highly expressed in embryonic development at the 8-cell stage and blastocyst. Expressed on activated T lymphocytes.
- Function
- Plays a critical role in immune responses and the development of atopic diseases
- Ligand/Receptor
- Binds to Sema4A
- Cell Type
- T cells, Embryonic Stem Cells
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
-
1. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
2. Kumanogoh A, et al. 2002. Nature 419:629.
3. Chakravarti S, et al. 2005. J. Exp. Med. 202:437. - Gene ID
- 171284 View all products for this Gene ID
- UniProt
- View information about Tim-2 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Tim-2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse Tim-2 | RMT2-1 | FC |
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Purified anti-mouse Tim-2
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