- Clone
- N212/17 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TPR-containing Rab8B-interacting protein, PEX5L, Tetratricopeptide Repeat-Containing Rab8b-Interacting Protein, HCN Channel Auxiliary Subunit, PEX5RP, PXR2B
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
601452 | 100 µg | 132€ |
TRIP8b is a protein that binds to and regulates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, an important class of voltage-gated channels. Binding of TRIP8b to HCN channels causes them to open at more hyperpolarized potentials, as TRIP8b antagonizes the binding of cyclic nucleotides. Additionally, TRIP8b affects HCN channel subcellular localization. Via these functions, TRIP8b plays a role in learning and memory, major depressive disorder, and epilepsy.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant protein corresponding to the N-terminus of rat TRIP8b
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
WB - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg/mL is suggested. For western blotting, the suggested use of this reagent is 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Does not react with human in Western blot. Lysates were heated at 50°C for ten minutes prior to electrophoresis.
- RRID
-
AB_2904443 (BioLegend Cat. No. 601452)
Antigen Details
- Structure
- TRIP8b is a 626 amino-acid protein with a predicted molecular weight of 70 kD.
- Distribution
-
Expressed in the cell membrane and cytoplasm, with elevated expression in neurons and the parathyroid gland
- Function
- Regulates cell-surface localization and cyclic nucleotide dependence of HCN channels
- Interaction
- RAB8B, HCN1, HCN2, HCN3
- Molecular Family
- Postsynaptic proteins
- Antigen References
-
- Han Y, et al. 2020. Channels (Austin). 14(1):110-122.
- Gene ID
- 51555 View all products for this Gene ID
- UniProt
- View information about TRIP8b on UniProt.org
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