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APC anti-mouse β2-microglobulin Antibody

Pricing & Availability
Clone
A16041A (See other available formats)
Regulatory Status
RUO
Other Names
Ly-m11, beta2m, beta2-m
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
A16041A_APC_beta2-microglobulin_Antibody_103117
C57BL/6 mouse splenocytes were stained with APC anti-mouse β2-microglobulin (clone A16041A; filled histogram) or with APC rat IgG2a, κ isotype control (open histogram).
  • A16041A_APC_beta2-microglobulin_Antibody_103117
    C57BL/6 mouse splenocytes were stained with APC anti-mouse β2-microglobulin (clone A16041A; filled histogram) or with APC rat IgG2a, κ isotype control (open histogram).
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154505 25 µg 120€
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154506 100 µg 271€
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Description

Beta 2-microglobulin (β2M) is a 12 kDa, Ig like, non-membrane-anchored glycoprotein. It non-covalently associates with MHC class I heavy chain and some Class I-like molecules and serves as the light chain. In association with MHC class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role in stabilizing MHC class I complexes for antigen presentation. In humans, circulating β2M levels are elevated in autoimmune/inflammatory disorders, viral infections, and glomerular filtration disorders.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant Mouse B2M
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Ren J, et al. 2022. J Clin Invest. . PubMed
  2. Hofbauer D, et al. 2021. Immunity. 54(8):1772-1787.e9. PubMed
RRID
AB_2721308 (BioLegend Cat. No. 154505)
AB_2721308 (BioLegend Cat. No. 154506)

Antigen Details

Structure
12 kD, Ig like glycoprotein
Distribution

Leukocytes, platelets, endothelial cells, epithelial cells

Function
Component of MHC class I complex
Ligand/Receptor
TCR (through MHC class I)
Cell Type
Endothelial cells, Epithelial cells, Leukocytes, Platelets
Biology Area
Immunology
Molecular Family
MHC Antigens
Antigen References
  1. Bernier GM, 1980, ox Sang, 38:323.
  2. Williams A, et al, 2002, Tissue Antigens, 59:3.
  3. Williams DB, et al, 1989, J. Immunol, 142:2796.
  4. Benoit LA, et al. 2007, J Immunol, 179:3588.
Gene ID
12010 View all products for this Gene ID
UniProt
View information about beta2-microglobulin on UniProt.org
Go To Top Version: 0    Revision Date: 11.01.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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