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PE anti-human CD70 Antibody

Pricing & Availability
Clone
113-16 (See other available formats)
Regulatory Status
RUO
Other Names
CD27 ligand, CD27L, Ki-24 antigen, Tumor necrosis factor ligand superfamily, member 7 (TNFSF7)
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
113-16_PE_070212
Human myeloma cell line, U266, was stained with CD70 (clone 113-16) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • 113-16_PE_070212
    Human myeloma cell line, U266, was stained with CD70 (clone 113-16) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
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355103 25 tests £105
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355104 100 tests £247
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Description

CD70, also known as CD27L, is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. CD70 costimulates T cell proliferation and differentiation. It plays a role in the pDC-induced B cell differentiation. The ligand of CD70 is CD27.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
CD70-transfected L cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion1.

Application References

(PubMed link indicates BioLegend citation)
  1. Shaw J, et al. 2010. Blood 115:3051. (Block)
Product Citations
  1. Gerace D, et al. 2023. Cell Rep Med. 4:100879. PubMed
  2. Wenthe J, et al. 2021. Cancer Immunology Immunotherapy. . PubMed
  3. Eriksson E, et al. 2016. Gene Ther. 10.1038/gt.2016.80. PubMed
  4. Yu X, et al. 2020. Cancer Cell. 37(6):850-866. PubMed
  5. Perna F, et al. 2017. Cancer Cell. 32:506. PubMed
RRID
AB_2561430 (BioLegend Cat. No. 355103)
AB_2561430 (BioLegend Cat. No. 355104)

Antigen Details

Structure
Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD
Distribution

Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas

Function
Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation
Ligand/Receptor
CD27
Cell Type
B cells, Dendritic cells, NK cells, T cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Bowman MR, et al. 1994. J. Immunol. 152:1756.
2. Shaw J, et al. 2010. Blood 115:3051.
3. Keller AM, et al. 2009. Blood 113:5167.

Gene ID
970 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD70
Specificity Alt (DOES NOT SHOW ON TDS):
CD70
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about CD70 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 06/15/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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