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PE anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
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Product Citations
publications
BM8_PE_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
  • BM8_PE_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
Compare all formats See PE spectral data
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123109 25 µg £30
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123110 100 µg £97
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Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Wang L, et al. 2021. J Nanobiotechnology. 19:56. PubMed
  2. Chen G, et al. 2021. J Mol Cell Cardiol. 159:62. PubMed
  3. Qin YY, et al. 2022. Mol Ther. 30:881. PubMed
  4. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  5. Zhou Y, et al. 2022. Br J Pharmacol. 179:1978. PubMed
  6. Zhang D, et al. 2022. Cell Stem Cell. 29:232. PubMed
  7. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  8. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  9. van Dierendonck XAMH, et al. 2022. Proc Natl Acad Sci U S A. 119:e2114739119. PubMed
  10. Helfen A, et al. 2022. Neoplasia. 28:100792. PubMed
  11. Pan L, et al. 2022. Mol Immunol. 147:101. PubMed
  12. Chae CS, et al. 2022. Cancer Discov. 12:1904. PubMed
  13. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  14. Campisi L, et al. 2022. Nature. 606:945. PubMed
  15. Gupta S, et al. 2022. Sci Adv. 8:eabn4886. PubMed
  16. Mendivil-Perez M, et al. 2022. Med Oncol. 40:15. PubMed
  17. Liu M, et al. 2022. Cells. 11: . PubMed
  18. Wang Y, et al. 2022. Cell Rep. 41:111738. PubMed
  19. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  20. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  21. García-García A, et al. 2023. Bioact Mater. 24:174. PubMed
  22. Glaubitz J, et al. 2023. Gut. :. PubMed
  23. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  24. Zhang K, et al. 2023. Nat Metab. 5:129. PubMed
  25. Wang D, et al. 2023. J Exp Clin Cancer Res. 42:26. PubMed
  26. Hattori Y, et al. 2023. Cell Rep. 42:112092. PubMed
  27. Yeh CH, et al. 2022. Immunity. 55:272. PubMed
  28. Ye B, et al. 2022. Cell Mol Immunol. 19:619. PubMed
  29. Meacham CE, et al. 2022. Nat Cell Biol. 24:697. PubMed
  30. Hasan Z, et al. 2013. Am J Physiol Lung Cell Mol Physiol. 304:221. PubMed
  31. Lee T, et al. 2014. Mol Biol Cell. 25:583. PubMed
  32. Peterson T, et al. 2016. Proc Natl Acad Sci U S A. 113: 4470-4475. PubMed
  33. Wang L, et al. 2020. Front Cell Dev Biol. 0.745138889. PubMed
  34. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  35. Morris CR, et al. 2022. Mucosal Immunol. 15:977. PubMed
  36. Sia ZR, et al. 2022. J Virol. 96:e0100622. PubMed
  37. Barsheshet Y, et al. 2022. Int J Mol Sci. 23:. PubMed
  38. Huang Q, et al. 2023. Immun Inflamm Dis. 11:e779. PubMed
  39. Li L, et al. 2023. iScience. 26:106095. PubMed
  40. Zhang X, et al. 2023. Heliyon. 9:e13490. PubMed
  41. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  42. Barberio AE, et al. 2023. Bioeng Transl Med. 8:e10453. PubMed
  43. Gupta T, et al. 2023. Front Immunol. 14:1044703. PubMed
  44. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  45. Han S, et al. 2023. Int J Mol Sci. 24:. PubMed
  46. Thai LM, et al. 2023. iScience. 26:106477. PubMed
  47. Chen S, et al. 2023. J Immunother Cancer. 11:. PubMed
  48. Duan JL, et al. 2023. Nat Aging. 3:258. PubMed
  49. Kaur N, et al. 2023. Heliyon. 9:e14952. PubMed
  50. Yang Y, et al. 2023. Diagnostics (Basel). 13:. PubMed
  51. Tang M, et al. 2023. Sci Adv. 9:eade6624. PubMed
  52. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  53. Tan T, et al. 2019. Nat Commun. 10:3322. PubMed
  54. Man SM et al. 2016. Cell. 167(2):382-396 . PubMed
  55. Zhao Y, et al. 2019. Mucosal Immunol. 1.298611111. PubMed
  56. Wang Q, et al. 2019. FASEB Bioadv. 1:609. PubMed
  57. Gordan S, et al. 2020. Cell Reports. 29(10):3033-3046.e4.. PubMed
  58. Kim SS, et al. 2022. Cancers (Basel). 14:. PubMed
  59. Yildirim Z, et al. 2022. EMBO Mol Med. 14:e15344. PubMed
  60. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  61. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  62. Gan C, et al. 2022. Respir Res. 23:32. PubMed
  63. El-Hindi K, et al. 2022. Int J Mol Sci. 23:. PubMed
  64. Meng W, et al. 2021. JCI Insight. 6:. PubMed
  65. Pathak JL, et al. 2021. Front Cell Dev Biol. 628139:9. PubMed
  66. Huang J, et al. 2021. Immunity. 54(4):673-686.e4. PubMed
  67. Kaczanowska S, et al. 2021. Cell. 184(8):2033-2052.e21. PubMed
  68. Karki R, et al. 2016. Nature. 10.1038/nature20597. PubMed
  69. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  70. Kloepper J, et al. 2016. Proc Natl Acad Sci U S A. 113: 4476-4481. PubMed
  71. O'Donnell C, et al. 2015. Br J Cancer. 114: 37 - 43. PubMed
  72. Maltby S, et al. 2014. J Immunol. 193:4072. PubMed
  73. Jackson A, et al. 2014. J Leukoc Biol. 92:609. PubMed
  74. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  75. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  76. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  77. Fu R, et al. 2020. Sci Rep. 10:1455. PubMed
  78. Groza D, et al. 2018. Oncoimmunology. 7:e1424676. PubMed
  79. Li Y, et al. 2021. Basic Res Cardiol. 116:30. PubMed
  80. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  81. Morgan PK, et al. 2021. J Biol Chem. 297:101341. PubMed
  82. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  83. Shen Y, et al. 2021. Comput Struct Biotechnol J. 19:5360. PubMed
  84. Zhang J, et al. 2021. Front Cardiovasc Med. 8:737652. PubMed
  85. Matsushita Y, et al. 2021. J Bone Miner Res. 36:1145. PubMed
  86. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  87. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  88. Palacios LM, et al. 2022. Biology (Basel). 11:. PubMed
  89. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  90. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  91. Yu S, et al. 2016. J Immunol. 197: 256 - 265. PubMed
  92. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  93. Guo HX, et al. 2018. World J Gastroenterol. 24:1779. PubMed
  94. Karki R et al. 2018. Cell. 173(4):920-933 . PubMed
  95. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  96. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  97. Chen J, et al. 2022. Nat Commun. 13:6759. PubMed
  98. Wang S, et al. 2022. Front Immunol. 13:869061. PubMed
  99. Gopinathan G, et al. 2022. Mol Cancer Ther. 21:1030. PubMed
  100. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  101. Yu X, et al. 2021. Nature. 594:560. PubMed
  102. Wei Q, et al. 2021. Nat Commun. 12:2522. PubMed
  103. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  104. Jenull S, et al. 2021. Cell Reports. 36(3):109406. PubMed
  105. Yuan Q, et al. 2021. Cell Reports. 34(5):108724. PubMed
  106. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
  107. Barberio AE, et al. 2020. ACS Nano. 14:11238. PubMed
  108. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  109. Li T, et al. 2016. Cell Death Dis. 7:e2258. PubMed
  110. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  111. Tang E, et al. 2015. J Lipid Res. 56:358. PubMed
  112. Harel M, et al. 2020. Cell. 179(1):236-250.e18.. PubMed
  113. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  114. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  115. Agelidis A, et al. 2019. Front Immunol. 10:500. PubMed
  116. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  117. Truax AD et al. 2018. Cell host & microbe. 24(3):364-378 . PubMed
  118. Rashid K, et al. 2018. Sci Rep. 8:9023. PubMed
  119. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  120. Almutairi F, et al. 2021. Front Immunol. 12:772288. PubMed
  121. Dignum T, et al. 2021. Cell Rep. 36:109675. PubMed
  122. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  123. Sugimoto C, et al. 2022. Elife. 11:. PubMed
  124. Nabeta HW, et al. 2022. Front Cell Infect Microbiol. 12:976033. PubMed
  125. Liu Z, et al. 2015. Biol Reprod. 92:63. PubMed
  126. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  127. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  128. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  129. Tencati M, Tapping R 2016. Infect Immun . 84: 2904 - 2913. PubMed
  130. Liao Y, et al. 2017. Virol J. 10.1186/s12985-017-0801-x. PubMed
  131. Dong G, et al. 2017. Biochim Biophys Acta. 10.1016/j.bbadis.2017.08.005. PubMed
  132. Tamura R, et al. 2017. Inflamm Regen. 36:26:00. PubMed
  133. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  134. Demircioglu F, et al. 2020. Nat Commun. 11:1290. PubMed
  135. Kimura T, et al. 2020. Commun Biol. 0.527777778. PubMed
  136. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  137. Sun P, et al. 2021. J Invest Dermatol. 141:1542. PubMed
  138. Li Y, et al. 2022. Clin Transl Immunology. 11:e1362. PubMed
  139. Sugita J, et al. 2021. Nat Commun. 12:1910. PubMed
  140. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  141. Kovacs L, et al. 2020. PLoS One. 15:e0240455. PubMed
  142. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  143. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  144. Hyatt L, et al. 2014. PLoS One. 9:109072. PubMed
  145. Yuan B, et al. 2021. J Immunother Cancer. 9:. PubMed
  146. Wu X, et al. 2021. Elife. 10:. PubMed
  147. Wang B, et al. 2022. Nat Commun. 13:3821. PubMed
  148. Opzoomer JW, et al. 2021. Sci Adv. 7:eabg9518. PubMed
  149. Glass A, et al. 2013. J Immunol. 190:4830. PubMed
  150. Izquierdo-Useros N, et al. 2014. J Immunol . 192:4852-4858. PubMed
  151. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  152. Liu Z, et al. 2016. J Biol Chem. 291: 1441 - 1447. PubMed
  153. Cheng XS, et al. 2020. J Cell Mol Med. 24:8391. PubMed
  154. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  155. Lumbroso D, et al. 2018. Front Immunol. 9:358. PubMed
  156. Simonneau M, et al. 2018. Oncotarget. 9:36457. PubMed
  157. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  158. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  159. Lee J, et al. 2022. Nat Commun. 13:1516. PubMed
  160. Ma K, et al. 2021. J Leukoc Biol. 110:927. PubMed
  161. Kornstädt L, et al. 2021. Front Immunol. 11:607048. PubMed
  162. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  163. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  164. Wang H, et al. 2021. Malar J. 20:249. PubMed
  165. Wang Q, et al. 2020. Res Sq. . PubMed
  166. Hofbauer D, et al. 2021. Immunity. 54(8):1772-1787.e9. PubMed
  167. Lin J, et al. 2017. Sci Rep. 7:41722. PubMed
  168. Yin T, et al. 2016. Sci Rep. 18:19534. PubMed
  169. Mitsuhashi A, et al. 2015. Nat Commun. 6: 8792. PubMed
  170. Eichin D, et al. 2015. PLoS One. 10: 0134721. PubMed
  171. Barman PK, et al. 2019. J Immunol. 202:2720. PubMed
  172. Das LM, et al. 2019. Autophagy. 15:813. PubMed
  173. Pelka K, et al. 2018. Immunity. 48:911. PubMed
  174. Lim D, et al. 2018. Front Physiol. 9:47. PubMed
  175. Iizasa E, et al. 2021. Nat Commun. 12:2299. PubMed
  176. Hu M, et al. 2021. J Clin Invest. 131:. PubMed
  177. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  178. Chen W, et al. 2016. J Immunol. 197: 3554 - 3565. PubMed
  179. Enam SF, et al. 2020. J Neuroinflammation. 0.845138889. PubMed
  180. Li N, et al. 2021. eLife. 10:00. PubMed
  181. Penninger P, et al. 2021. STAR Protocols. 2(1):100352. PubMed
  182. Zhang F, et al. 2020. EMBO Mol Med. e12034:12. PubMed
  183. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  184. Kumaran Satyanarayanan S, et al. 2019. Nat Commun. 10:3471. PubMed
  185. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  186. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  187. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  188. Xu M, et al. 2022. Genes Dis. 9:429. PubMed
  189. Myerson JW, et al. 2021. Nat Nanotechnol. Online ahead of print. PubMed
  190. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  191. Zhu H, et al. 2021. Cell Metabolism. :. PubMed
  192. Kuai Y, et al. 2020. Theranostics. 5.099305556. PubMed
  193. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  194. Wang C, et al. 2017. J Ethnopharmacol. 10.1016/j.jep.2017.06.014. PubMed
  195. Bai B, et al. 2021. Theranostics. 11:6225. PubMed
  196. Huang Z, et al. 2021. Nat Commun. 12:145. PubMed
  197. Cho K, et al. 2021. iScience. 24:103117. PubMed
  198. Ma S, et al. 2022. Cell Rep. 38:110520. PubMed
  199. Sharma S, et al. 2021. Pathophysiology. 28:501. PubMed
  200. Nishida J, et al. 2022. STAR Protoc. 3:101306. PubMed
  201. McDonald B, et al. 2020. Cell Host Microbe. 28(5):660-668.e4. PubMed
  202. Devi S, et al. 2021. Immunity. 54(6):1219-1230.e7. PubMed
  203. Qin Q, et al. 2021. Cell Reports. 35(8):109161. PubMed
  204. Riedelberger M, et al. 2020. Bio Protoc. e3552:10. PubMed
  205. Michaud J, et al. 2017. BMC Microbiology . 10.1186/s12866-017-1036-0. PubMed
  206. Toomey CB, et al. 2018. Invest Ophthalmol Vis Sci. 59:662. PubMed
  207. Sun T, et al. 2017. Mucosal Immunol. 0.954861111. PubMed
  208. Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
  209. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  210. Li H, et al. 2022. Gut Microbes. 14:2127456. PubMed
  211. Li Y, et al. 2022. Front Cardiovasc Med. 9:830781. PubMed
  212. Sun S, et al. 2021. Front Immunol. 12:777665. PubMed
  213. Fields L, et al. 2021. Mol Ther. 29:2554. PubMed
  214. Jiang Y, et al. 2021. Cell Death Differ. 28:3009. PubMed
  215. Murr NJ, et al. 2021. Nutrients. 13:. PubMed
  216. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  217. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  218. Reimer E, et al. 2020. J Cell Sci. 134:00:00. PubMed
  219. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  220. Alonso-Herranz L, et al. 2020. Elife. 9:00. PubMed
  221. Pashover-Schallinger E, et al. 2012. FASEB J. 26:3891. PubMed
  222. Min C, et al. 2020. Cell Death Dis. 0.847916667. PubMed
  223. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  224. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  225. Sendler M, et al. 2020. Gastroenterology. 158:253. PubMed
  226. Pagan JD, et al. 2018. Cell. 172:564. PubMed
  227. Hu Y, et al. 2021. Cell Death Dis. 12:743. PubMed
  228. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  229. Kolodkin-Gal D, et al. 2021. Gut. Online ahead of print. PubMed
  230. Fu Y, et al. 2021. Front Cell Dev Biol. 9:689727. PubMed
  231. Andriessen EMMA, et al. 2021. EMBO Mol Med. 13:e11754. PubMed
  232. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  233. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  234. Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed
  235. Zhang S, et al. 2014. Eur J Pharmacol. 733:45. PubMed
  236. Kumagai S, et al. 2016. Cardiovasc Res. 109: 272 - 282. PubMed
  237. Ikezoe K, et al. 2016. Sci Rep. 6: 25781. PubMed
  238. Hasegawa T, et al. 2020. Sci Rep. 10:13480. PubMed
  239. Wang H, et al. 2020. Nat Mater. 1.655555556. PubMed
  240. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  241. Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
  242. Li B, et al. 2019. Oncol Rep. 41:608. PubMed
  243. Lamb T, et al. 2022. Toxics. 10:. PubMed
  244. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  245. Song J, et al. 2021. Am J Physiol Heart Circ Physiol. 320:H323. PubMed
  246. Li ZL, et al. 2021. Mol Ther Nucleic Acids. 25:502. PubMed
  247. Tang Z, et al. 2021. Stem Cell Res Ther. 12:397. PubMed
  248. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  249. Morikawa M, et al. 2016. PLoS One. 11:e0163607. PubMed
  250. Yahuafai J, et al. 2014. J Control Release. 28:192. PubMed
  251. Sun X, et al. 2020. Cell Metabolism. 31(1):189-206.e8.. PubMed
  252. Yu JM, et al. 2019. Nat Commun. 4.388888889. PubMed
  253. Nowak W, et al. 2020. EBioMedicine. 50:290-305.. PubMed
  254. Hightower RM, et al. 2019. Mol Ther. 28:189. PubMed
  255. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  256. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  257. Bitschar K, et al. 2019. Nat Commun. 10:2730. PubMed
  258. Doni A, et al. 2021. Nat Commun. 12:3739. PubMed
  259. Kang M, et al. 2021. Front Cell Dev Biol. 8:596622. PubMed
  260. He S, et al. 2021. Front Pharmacol. 12:743837. PubMed
  261. Wang S, et al. 2022. J Inflamm Res. 14:7107. PubMed
  262. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  263. Al-Barwani F, et al. 2014. PLoS One. 9:104523. PubMed
  264. Lieber S, et al. 2014. Mol Pharmacol. 87:162. PubMed
  265. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  266. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  267. Yang H, et al. 2020. Arterioscler Thromb Vasc Biol. 40:e350. PubMed
  268. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  269. Sundar I, et al. 2017. Biochem Biophys Res Commun. 10.1016/j.bbrc.2017.09.157. PubMed
  270. Maniati E, et al. 2020. Cell Rep. 30:525. PubMed
  271. Han MS, et al. 2020. Proc Natl Acad Sci U S A. 117:2751. PubMed
  272. Ayturk UM, et al. 2020. J Bone Miner Res. 35:1981. PubMed
  273. Huang T, et al. 2022. Nat Commun. 13:3489. PubMed
  274. Sun L, et al. 2022. Adv Sci (Weinh). 9:e2104051. PubMed
  275. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  276. Gao X, et al. 2021. Nature. 589:591. PubMed
  277. Lee SA, et al. 2021. Cells. 10:. PubMed
  278. Fan ZP, et al. 2021. Front Immunol. 12:743354. PubMed
  279. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  280. Valkenburg S, et al. 2016. Sci Rep. 6:22666. PubMed
  281. Wang Y, et al. 2020. eLife. 9:e57438.. PubMed
  282. Chen M, et al. 2019. Cell Stem Cell. 25:501. PubMed
  283. Moufarrij S, et al. 2020. Sci Rep. 10:3470. PubMed
  284. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  285. William M, et al. 2018. J Immunol. 200:4102. PubMed
  286. Sugita Y, et al. 2021. Oncol Rep. 45:. PubMed
  287. Zhang F, et al. 2021. J Immunol Res. 2021:5521051. PubMed
  288. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  289. Liu Q, et al. 2021. Adv Mater. 33:e2102852. PubMed
  290. Xiang Y, et al. 2014. Proc Natl Acad Sci U S A. . PubMed
  291. Erin N, et al. 2015. Brain Behav Immun. 48: 174-185. PubMed
  292. Peng X, et al. 2015. J Immunol. 195: 2797-2805. PubMed
  293. Tsunekuni K, et al. 2020. J Clin Med. 9:00. PubMed
  294. Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed
  295. Hering L, et al. 2020. Front Immunol. 1.747222222. PubMed
  296. Silva-Cayetano A, et al. 2020. Med. 2(3):243-262.e8. PubMed
  297. Asada S, et al. 2018. Nat Commun. 9:2733. PubMed
  298. Zhang J, et al. 2018. Oncoimmunology. 7:e1461301. PubMed
  299. Hayashida E, et al. 2019. J Neuroinflammation. 0.789583333. PubMed
  300. Wang S, et al. 2020. J Cell Mol Med. 24:722. PubMed
  301. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  302. Xu M, et al. 2020. Cell. 178(6):1478-1492.e20.. PubMed
  303. Wang Q, et al. 2020. Respir Res. 0.981944444. PubMed
  304. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  305. Zhu Y, et al. 2021. Int J Oral Sci. 13:25. PubMed
  306. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  307. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  308. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  309. Nakayama Y, et al. 2020. Proc Natl Acad Sci U S A. 117:14365. PubMed
  310. Smith R, et al. 2016. J Leukoc Biol. 100:371-80. PubMed
  311. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  312. Zhang J, et al. 2014. J Immunol. 193:5149. PubMed
  313. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  314. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  315. Lee MC, et al. 2017. J Immunol. 198:3565. PubMed
  316. Perrotta C, et al. 2018. Front Immunol. 9:1186. PubMed
  317. Jiang M, et al. 2021. Front Pharmacol. 12:657486. PubMed
  318. Song HY, et al. 2021. Mol Ther. S1525-0016:00472-X. PubMed
  319. Luo ZW, et al. 2021. Int J Nanomedicine. 16:2949. PubMed
  320. Wang X, et al. 2021. Sci Transl Med. 13:. PubMed
  321. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  322. Lau A, et al. 2022. Sci Adv. 8:eabm0142. PubMed
  323. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  324. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  325. Petty AJ, et al. 2021. JCI Insight. 6:. PubMed
  326. Gawish R, et al. 2022. Elife. 11:. PubMed
  327. Jia J, et al. 2022. Nat Commun. 13:6804. PubMed
  328. Horwitz E, et al. 2014. Cancer Discovery. 4:730. PubMed
  329. Wang Y, et al. 2015. Sci Rep. 5:16973. PubMed
  330. Ang QY, et al. 2020. Cell. 181(6):1263-1275.e16. PubMed
  331. Wang X, et al. 2020. Immunity. 328:52. PubMed
  332. Li Z et al. 2018. Immunity. 49(4):640-653 . PubMed
  333. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  334. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  335. Wang L, et al. 2020. J Nanobiotechnology. 18:38. PubMed
  336. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  337. Xu Z, et al. 2022. Cell Death Dis. 13:502. PubMed
  338. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  339. Wu KKL, et al. 2021. Nat Commun. 12:6637. PubMed
  340. Witas R, et al. 2021. Int J Mol Sci. 22:. PubMed
  341. Feng L, et al. 2014. Biochem Pharmacol. 89:109. PubMed
  342. Liu Y, et al. 2019. Am J Physiol Cell Physiol. 317:C762. PubMed
  343. Samir P, et al. 2019. Nature. 573:590. PubMed
  344. Abe H, et al. 2019. Nat Commun. 10:2824. PubMed
  345. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
RRID
AB_893486 (BioLegend Cat. No. 123109)
AB_893486 (BioLegend Cat. No. 123110)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
F4/80
Specificity Alt (DOES NOT SHOW ON TDS):
F4/80
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about F4/80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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