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PE anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
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Product Citations
publications
BM8_PE_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
  • BM8_PE_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
Compare all formats See PE spectral data
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123109 25 µg £30
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123110 100 µg £97
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Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Hasan Z, et al. 2013. Am J Physiol Lung Cell Mol Physiol. 304:221. PubMed
  2. Lee T, et al. 2014. Mol Biol Cell. 25:583. PubMed
  3. Peterson T, et al. 2016. Proc Natl Acad Sci U S A. 113: 4470-4475. PubMed
  4. Wang L, et al. 2020. Front Cell Dev Biol. 0.745138889. PubMed
  5. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  6. Wang L, et al. 2021. J Nanobiotechnology. 19:56. PubMed
  7. Chen G, et al. 2021. J Mol Cell Cardiol. 159:62. PubMed
  8. Qin YY, et al. 2022. Mol Ther. 30:881. PubMed
  9. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  10. Zhou Y, et al. 2022. Br J Pharmacol. 179:1978. PubMed
  11. Zhang D, et al. 2022. Cell Stem Cell. 29:232. PubMed
  12. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  13. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  14. van Dierendonck XAMH, et al. 2022. Proc Natl Acad Sci U S A. 119:e2114739119. PubMed
  15. Helfen A, et al. 2022. Neoplasia. 28:100792. PubMed
  16. Pan L, et al. 2022. Mol Immunol. 147:101. PubMed
  17. Chae CS, et al. 2022. Cancer Discov. 12:1904. PubMed
  18. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  19. Campisi L, et al. 2022. Nature. 606:945. PubMed
  20. Gupta S, et al. 2022. Sci Adv. 8:eabn4886. PubMed
  21. Mendivil-Perez M, et al. 2022. Med Oncol. 40:15. PubMed
  22. Liu M, et al. 2022. Cells. 11: . PubMed
  23. Wang Y, et al. 2022. Cell Rep. 41:111738. PubMed
  24. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  25. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  26. García-García A, et al. 2023. Bioact Mater. 24:174. PubMed
  27. Glaubitz J, et al. 2023. Gut. :. PubMed
  28. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  29. Zhang K, et al. 2023. Nat Metab. 5:129. PubMed
  30. Wang D, et al. 2023. J Exp Clin Cancer Res. 42:26. PubMed
  31. Hattori Y, et al. 2023. Cell Rep. 42:112092. PubMed
  32. Yeh CH, et al. 2022. Immunity. 55:272. PubMed
  33. Ye B, et al. 2022. Cell Mol Immunol. 19:619. PubMed
  34. Meacham CE, et al. 2022. Nat Cell Biol. 24:697. PubMed
  35. Morris CR, et al. 2022. Mucosal Immunol. 15:977. PubMed
  36. Sia ZR, et al. 2022. J Virol. 96:e0100622. PubMed
  37. Barsheshet Y, et al. 2022. Int J Mol Sci. 23:. PubMed
  38. Huang Q, et al. 2023. Immun Inflamm Dis. 11:e779. PubMed
  39. Li L, et al. 2023. iScience. 26:106095. PubMed
  40. Zhang X, et al. 2023. Heliyon. 9:e13490. PubMed
  41. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  42. Barberio AE, et al. 2023. Bioeng Transl Med. 8:e10453. PubMed
  43. Gupta T, et al. 2023. Front Immunol. 14:1044703. PubMed
  44. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  45. Han S, et al. 2023. Int J Mol Sci. 24:. PubMed
  46. Thai LM, et al. 2023. iScience. 26:106477. PubMed
  47. Chen S, et al. 2023. J Immunother Cancer. 11:. PubMed
  48. Duan JL, et al. 2023. Nat Aging. 3:258. PubMed
  49. Kaur N, et al. 2023. Heliyon. 9:e14952. PubMed
  50. Yang Y, et al. 2023. Diagnostics (Basel). 13:. PubMed
  51. Tang M, et al. 2023. Sci Adv. 9:eade6624. PubMed
  52. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  53. Tan T, et al. 2019. Nat Commun. 10:3322. PubMed
  54. Man SM et al. 2016. Cell. 167(2):382-396 . PubMed
  55. Zhao Y, et al. 2019. Mucosal Immunol. 1.298611111. PubMed
  56. Wang Q, et al. 2019. FASEB Bioadv. 1:609. PubMed
  57. Gordan S, et al. 2020. Cell Reports. 29(10):3033-3046.e4.. PubMed
  58. Pathak JL, et al. 2021. Front Cell Dev Biol. 628139:9. PubMed
  59. Huang J, et al. 2021. Immunity. 54(4):673-686.e4. PubMed
  60. Kaczanowska S, et al. 2021. Cell. 184(8):2033-2052.e21. PubMed
  61. Karki R, et al. 2016. Nature. 10.1038/nature20597. PubMed
  62. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  63. Kloepper J, et al. 2016. Proc Natl Acad Sci U S A. 113: 4476-4481. PubMed
  64. O'Donnell C, et al. 2015. Br J Cancer. 114: 37 - 43. PubMed
  65. Maltby S, et al. 2014. J Immunol. 193:4072. PubMed
  66. Jackson A, et al. 2014. J Leukoc Biol. 92:609. PubMed
  67. Kim SS, et al. 2022. Cancers (Basel). 14:. PubMed
  68. Yildirim Z, et al. 2022. EMBO Mol Med. 14:e15344. PubMed
  69. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  70. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  71. Gan C, et al. 2022. Respir Res. 23:32. PubMed
  72. El-Hindi K, et al. 2022. Int J Mol Sci. 23:. PubMed
  73. Meng W, et al. 2021. JCI Insight. 6:. PubMed
  74. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  75. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  76. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  77. Fu R, et al. 2020. Sci Rep. 10:1455. PubMed
  78. Groza D, et al. 2018. Oncoimmunology. 7:e1424676. PubMed
  79. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  80. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  81. Yu S, et al. 2016. J Immunol. 197: 256 - 265. PubMed
  82. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  83. Li Y, et al. 2021. Basic Res Cardiol. 116:30. PubMed
  84. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  85. Morgan PK, et al. 2021. J Biol Chem. 297:101341. PubMed
  86. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  87. Shen Y, et al. 2021. Comput Struct Biotechnol J. 19:5360. PubMed
  88. Zhang J, et al. 2021. Front Cardiovasc Med. 8:737652. PubMed
  89. Matsushita Y, et al. 2021. J Bone Miner Res. 36:1145. PubMed
  90. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  91. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  92. Palacios LM, et al. 2022. Biology (Basel). 11:. PubMed
  93. Guo HX, et al. 2018. World J Gastroenterol. 24:1779. PubMed
  94. Karki R et al. 2018. Cell. 173(4):920-933 . PubMed
  95. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  96. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  97. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  98. Jenull S, et al. 2021. Cell Reports. 36(3):109406. PubMed
  99. Yuan Q, et al. 2021. Cell Reports. 34(5):108724. PubMed
  100. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
  101. Barberio AE, et al. 2020. ACS Nano. 14:11238. PubMed
  102. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  103. Li T, et al. 2016. Cell Death Dis. 7:e2258. PubMed
  104. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  105. Tang E, et al. 2015. J Lipid Res. 56:358. PubMed
  106. Chen J, et al. 2022. Nat Commun. 13:6759. PubMed
  107. Wang S, et al. 2022. Front Immunol. 13:869061. PubMed
  108. Gopinathan G, et al. 2022. Mol Cancer Ther. 21:1030. PubMed
  109. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  110. Yu X, et al. 2021. Nature. 594:560. PubMed
  111. Wei Q, et al. 2021. Nat Commun. 12:2522. PubMed
  112. Harel M, et al. 2020. Cell. 179(1):236-250.e18.. PubMed
  113. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  114. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  115. Agelidis A, et al. 2019. Front Immunol. 10:500. PubMed
  116. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  117. Truax AD et al. 2018. Cell host & microbe. 24(3):364-378 . PubMed
  118. Rashid K, et al. 2018. Sci Rep. 8:9023. PubMed
  119. Liu Z, et al. 2015. Biol Reprod. 92:63. PubMed
  120. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  121. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  122. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  123. Tencati M, Tapping R 2016. Infect Immun . 84: 2904 - 2913. PubMed
  124. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  125. Almutairi F, et al. 2021. Front Immunol. 12:772288. PubMed
  126. Dignum T, et al. 2021. Cell Rep. 36:109675. PubMed
  127. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  128. Sugimoto C, et al. 2022. Elife. 11:. PubMed
  129. Nabeta HW, et al. 2022. Front Cell Infect Microbiol. 12:976033. PubMed
  130. Liao Y, et al. 2017. Virol J. 10.1186/s12985-017-0801-x. PubMed
  131. Dong G, et al. 2017. Biochim Biophys Acta. 10.1016/j.bbadis.2017.08.005. PubMed
  132. Tamura R, et al. 2017. Inflamm Regen. 36:26:00. PubMed
  133. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  134. Demircioglu F, et al. 2020. Nat Commun. 11:1290. PubMed
  135. Kimura T, et al. 2020. Commun Biol. 0.527777778. PubMed
  136. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  137. Kovacs L, et al. 2020. PLoS One. 15:e0240455. PubMed
  138. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  139. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  140. Hyatt L, et al. 2014. PLoS One. 9:109072. PubMed
  141. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  142. Sun P, et al. 2021. J Invest Dermatol. 141:1542. PubMed
  143. Li Y, et al. 2022. Clin Transl Immunology. 11:e1362. PubMed
  144. Sugita J, et al. 2021. Nat Commun. 12:1910. PubMed
  145. Glass A, et al. 2013. J Immunol. 190:4830. PubMed
  146. Izquierdo-Useros N, et al. 2014. J Immunol . 192:4852-4858. PubMed
  147. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  148. Liu Z, et al. 2016. J Biol Chem. 291: 1441 - 1447. PubMed
  149. Cheng XS, et al. 2020. J Cell Mol Med. 24:8391. PubMed
  150. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  151. Yuan B, et al. 2021. J Immunother Cancer. 9:. PubMed
  152. Wu X, et al. 2021. Elife. 10:. PubMed
  153. Wang B, et al. 2022. Nat Commun. 13:3821. PubMed
  154. Opzoomer JW, et al. 2021. Sci Adv. 7:eabg9518. PubMed
  155. Lumbroso D, et al. 2018. Front Immunol. 9:358. PubMed
  156. Simonneau M, et al. 2018. Oncotarget. 9:36457. PubMed
  157. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  158. Wang Q, et al. 2020. Res Sq. . PubMed
  159. Hofbauer D, et al. 2021. Immunity. 54(8):1772-1787.e9. PubMed
  160. Lin J, et al. 2017. Sci Rep. 7:41722. PubMed
  161. Yin T, et al. 2016. Sci Rep. 18:19534. PubMed
  162. Mitsuhashi A, et al. 2015. Nat Commun. 6: 8792. PubMed
  163. Eichin D, et al. 2015. PLoS One. 10: 0134721. PubMed
  164. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  165. Lee J, et al. 2022. Nat Commun. 13:1516. PubMed
  166. Ma K, et al. 2021. J Leukoc Biol. 110:927. PubMed
  167. Kornstädt L, et al. 2021. Front Immunol. 11:607048. PubMed
  168. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  169. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  170. Wang H, et al. 2021. Malar J. 20:249. PubMed
  171. Barman PK, et al. 2019. J Immunol. 202:2720. PubMed
  172. Das LM, et al. 2019. Autophagy. 15:813. PubMed
  173. Pelka K, et al. 2018. Immunity. 48:911. PubMed
  174. Lim D, et al. 2018. Front Physiol. 9:47. PubMed
  175. Chen W, et al. 2016. J Immunol. 197: 3554 - 3565. PubMed
  176. Enam SF, et al. 2020. J Neuroinflammation. 0.845138889. PubMed
  177. Li N, et al. 2021. eLife. 10:00. PubMed
  178. Penninger P, et al. 2021. STAR Protocols. 2(1):100352. PubMed
  179. Zhang F, et al. 2020. EMBO Mol Med. e12034:12. PubMed
  180. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  181. Iizasa E, et al. 2021. Nat Commun. 12:2299. PubMed
  182. Hu M, et al. 2021. J Clin Invest. 131:. PubMed
  183. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  184. Kumaran Satyanarayanan S, et al. 2019. Nat Commun. 10:3471. PubMed
  185. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  186. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  187. Zhu H, et al. 2021. Cell Metabolism. :. PubMed
  188. Kuai Y, et al. 2020. Theranostics. 5.099305556. PubMed
  189. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  190. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  191. Xu M, et al. 2022. Genes Dis. 9:429. PubMed
  192. Myerson JW, et al. 2021. Nat Nanotechnol. Online ahead of print. PubMed
  193. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  194. Wang C, et al. 2017. J Ethnopharmacol. 10.1016/j.jep.2017.06.014. PubMed
  195. McDonald B, et al. 2020. Cell Host Microbe. 28(5):660-668.e4. PubMed
  196. Devi S, et al. 2021. Immunity. 54(6):1219-1230.e7. PubMed
  197. Qin Q, et al. 2021. Cell Reports. 35(8):109161. PubMed
  198. Riedelberger M, et al. 2020. Bio Protoc. e3552:10. PubMed
  199. Bai B, et al. 2021. Theranostics. 11:6225. PubMed
  200. Huang Z, et al. 2021. Nat Commun. 12:145. PubMed
  201. Cho K, et al. 2021. iScience. 24:103117. PubMed
  202. Ma S, et al. 2022. Cell Rep. 38:110520. PubMed
  203. Sharma S, et al. 2021. Pathophysiology. 28:501. PubMed
  204. Nishida J, et al. 2022. STAR Protoc. 3:101306. PubMed
  205. Michaud J, et al. 2017. BMC Microbiology . 10.1186/s12866-017-1036-0. PubMed
  206. Toomey CB, et al. 2018. Invest Ophthalmol Vis Sci. 59:662. PubMed
  207. Sun T, et al. 2017. Mucosal Immunol. 0.954861111. PubMed
  208. Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
  209. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  210. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  211. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  212. Reimer E, et al. 2020. J Cell Sci. 134:00:00. PubMed
  213. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  214. Alonso-Herranz L, et al. 2020. Elife. 9:00. PubMed
  215. Pashover-Schallinger E, et al. 2012. FASEB J. 26:3891. PubMed
  216. Li H, et al. 2022. Gut Microbes. 14:2127456. PubMed
  217. Li Y, et al. 2022. Front Cardiovasc Med. 9:830781. PubMed
  218. Sun S, et al. 2021. Front Immunol. 12:777665. PubMed
  219. Fields L, et al. 2021. Mol Ther. 29:2554. PubMed
  220. Jiang Y, et al. 2021. Cell Death Differ. 28:3009. PubMed
  221. Murr NJ, et al. 2021. Nutrients. 13:. PubMed
  222. Min C, et al. 2020. Cell Death Dis. 0.847916667. PubMed
  223. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  224. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  225. Sendler M, et al. 2020. Gastroenterology. 158:253. PubMed
  226. Pagan JD, et al. 2018. Cell. 172:564. PubMed
  227. Zhang S, et al. 2014. Eur J Pharmacol. 733:45. PubMed
  228. Kumagai S, et al. 2016. Cardiovasc Res. 109: 272 - 282. PubMed
  229. Ikezoe K, et al. 2016. Sci Rep. 6: 25781. PubMed
  230. Hasegawa T, et al. 2020. Sci Rep. 10:13480. PubMed
  231. Wang H, et al. 2020. Nat Mater. 1.655555556. PubMed
  232. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  233. Hu Y, et al. 2021. Cell Death Dis. 12:743. PubMed
  234. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  235. Kolodkin-Gal D, et al. 2021. Gut. Online ahead of print. PubMed
  236. Fu Y, et al. 2021. Front Cell Dev Biol. 9:689727. PubMed
  237. Andriessen EMMA, et al. 2021. EMBO Mol Med. 13:e11754. PubMed
  238. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  239. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  240. Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed
  241. Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
  242. Li B, et al. 2019. Oncol Rep. 41:608. PubMed
  243. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  244. Morikawa M, et al. 2016. PLoS One. 11:e0163607. PubMed
  245. Yahuafai J, et al. 2014. J Control Release. 28:192. PubMed
  246. Lamb T, et al. 2022. Toxics. 10:. PubMed
  247. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  248. Song J, et al. 2021. Am J Physiol Heart Circ Physiol. 320:H323. PubMed
  249. Li ZL, et al. 2021. Mol Ther Nucleic Acids. 25:502. PubMed
  250. Tang Z, et al. 2021. Stem Cell Res Ther. 12:397. PubMed
  251. Sun X, et al. 2020. Cell Metabolism. 31(1):189-206.e8.. PubMed
  252. Yu JM, et al. 2019. Nat Commun. 4.388888889. PubMed
  253. Nowak W, et al. 2020. EBioMedicine. 50:290-305.. PubMed
  254. Hightower RM, et al. 2019. Mol Ther. 28:189. PubMed
  255. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  256. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  257. Bitschar K, et al. 2019. Nat Commun. 10:2730. PubMed
  258. Al-Barwani F, et al. 2014. PLoS One. 9:104523. PubMed
  259. Lieber S, et al. 2014. Mol Pharmacol. 87:162. PubMed
  260. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  261. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  262. Yang H, et al. 2020. Arterioscler Thromb Vasc Biol. 40:e350. PubMed
  263. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  264. Doni A, et al. 2021. Nat Commun. 12:3739. PubMed
  265. Kang M, et al. 2021. Front Cell Dev Biol. 8:596622. PubMed
  266. He S, et al. 2021. Front Pharmacol. 12:743837. PubMed
  267. Wang S, et al. 2022. J Inflamm Res. 14:7107. PubMed
  268. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  269. Sundar I, et al. 2017. Biochem Biophys Res Commun. 10.1016/j.bbrc.2017.09.157. PubMed
  270. Maniati E, et al. 2020. Cell Rep. 30:525. PubMed
  271. Han MS, et al. 2020. Proc Natl Acad Sci U S A. 117:2751. PubMed
  272. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  273. Valkenburg S, et al. 2016. Sci Rep. 6:22666. PubMed
  274. Ayturk UM, et al. 2020. J Bone Miner Res. 35:1981. PubMed
  275. Huang T, et al. 2022. Nat Commun. 13:3489. PubMed
  276. Sun L, et al. 2022. Adv Sci (Weinh). 9:e2104051. PubMed
  277. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  278. Gao X, et al. 2021. Nature. 589:591. PubMed
  279. Lee SA, et al. 2021. Cells. 10:. PubMed
  280. Fan ZP, et al. 2021. Front Immunol. 12:743354. PubMed
  281. Wang Y, et al. 2020. eLife. 9:e57438.. PubMed
  282. Chen M, et al. 2019. Cell Stem Cell. 25:501. PubMed
  283. Moufarrij S, et al. 2020. Sci Rep. 10:3470. PubMed
  284. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  285. William M, et al. 2018. J Immunol. 200:4102. PubMed
  286. Xiang Y, et al. 2014. Proc Natl Acad Sci U S A. . PubMed
  287. Erin N, et al. 2015. Brain Behav Immun. 48: 174-185. PubMed
  288. Peng X, et al. 2015. J Immunol. 195: 2797-2805. PubMed
  289. Tsunekuni K, et al. 2020. J Clin Med. 9:00. PubMed
  290. Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed
  291. Hering L, et al. 2020. Front Immunol. 1.747222222. PubMed
  292. Silva-Cayetano A, et al. 2020. Med. 2(3):243-262.e8. PubMed
  293. Sugita Y, et al. 2021. Oncol Rep. 45:. PubMed
  294. Zhang F, et al. 2021. J Immunol Res. 2021:5521051. PubMed
  295. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  296. Liu Q, et al. 2021. Adv Mater. 33:e2102852. PubMed
  297. Asada S, et al. 2018. Nat Commun. 9:2733. PubMed
  298. Zhang J, et al. 2018. Oncoimmunology. 7:e1461301. PubMed
  299. Hayashida E, et al. 2019. J Neuroinflammation. 0.789583333. PubMed
  300. Wang S, et al. 2020. J Cell Mol Med. 24:722. PubMed
  301. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  302. Xu M, et al. 2020. Cell. 178(6):1478-1492.e20.. PubMed
  303. Wang Q, et al. 2020. Respir Res. 0.981944444. PubMed
  304. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  305. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  306. Nakayama Y, et al. 2020. Proc Natl Acad Sci U S A. 117:14365. PubMed
  307. Smith R, et al. 2016. J Leukoc Biol. 100:371-80. PubMed
  308. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  309. Zhang J, et al. 2014. J Immunol. 193:5149. PubMed
  310. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  311. Zhu Y, et al. 2021. Int J Oral Sci. 13:25. PubMed
  312. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  313. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  314. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  315. Lee MC, et al. 2017. J Immunol. 198:3565. PubMed
  316. Perrotta C, et al. 2018. Front Immunol. 9:1186. PubMed
  317. Horwitz E, et al. 2014. Cancer Discovery. 4:730. PubMed
  318. Wang Y, et al. 2015. Sci Rep. 5:16973. PubMed
  319. Ang QY, et al. 2020. Cell. 181(6):1263-1275.e16. PubMed
  320. Wang X, et al. 2020. Immunity. 328:52. PubMed
  321. Jiang M, et al. 2021. Front Pharmacol. 12:657486. PubMed
  322. Song HY, et al. 2021. Mol Ther. S1525-0016:00472-X. PubMed
  323. Luo ZW, et al. 2021. Int J Nanomedicine. 16:2949. PubMed
  324. Wang X, et al. 2021. Sci Transl Med. 13:. PubMed
  325. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  326. Lau A, et al. 2022. Sci Adv. 8:eabm0142. PubMed
  327. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  328. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  329. Petty AJ, et al. 2021. JCI Insight. 6:. PubMed
  330. Gawish R, et al. 2022. Elife. 11:. PubMed
  331. Jia J, et al. 2022. Nat Commun. 13:6804. PubMed
  332. Li Z et al. 2018. Immunity. 49(4):640-653 . PubMed
  333. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  334. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  335. Wang L, et al. 2020. J Nanobiotechnology. 18:38. PubMed
  336. Feng L, et al. 2014. Biochem Pharmacol. 89:109. PubMed
  337. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  338. Xu Z, et al. 2022. Cell Death Dis. 13:502. PubMed
  339. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  340. Wu KKL, et al. 2021. Nat Commun. 12:6637. PubMed
  341. Witas R, et al. 2021. Int J Mol Sci. 22:. PubMed
  342. Liu Y, et al. 2019. Am J Physiol Cell Physiol. 317:C762. PubMed
  343. Samir P, et al. 2019. Nature. 573:590. PubMed
  344. Abe H, et al. 2019. Nat Commun. 10:2824. PubMed
  345. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
RRID
AB_893486 (BioLegend Cat. No. 123109)
AB_893486 (BioLegend Cat. No. 123110)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
F4/80
Specificity Alt (DOES NOT SHOW ON TDS):
F4/80
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about F4/80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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